Li J - Search Results

1

Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Wang Z, Jiang X, Zhang X, Tian G, Yang R, Wu J, Zou X, Liu Z, Yang X, Wu C, Shi J, Li J, Suo J, Wang Y, Zhang R, Xu Z, Gong X, He Y, Zhu W, Aisa HA, Jiang H, Xu Y, Shen J. Wang Z, et al. Among authors: li j. J Med Chem. 2019 May 23;62(10):4979-4990. doi: 10.1021/acs.jmedchem.9b00123. Epub 2019 May 8. J Med Chem. 2019. PMID: 31021628

2

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.

Duan H, Zheng J, Lai Q, Liu Z, Tian G, Wang Z, Li J, Shen J. Duan H, et al. Among authors: li j. Bioorg Med Chem Lett. 2009 May 15;19(10):2777-9. doi: 10.1016/j.bmcl.2009.03.125. Epub 2009 Mar 28. Bioorg Med Chem Lett. 2009. PMID: 19375311

3

Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.

Wang G, Liu Z, Chen T, Wang Z, Yang H, Zheng M, Ren J, Tian G, Yang X, Li L, Li J, Suo J, Zhang R, Jiang X, Terrett NK, Shen J, Xu Y, Jiang H. Wang G, et al. Among authors: li j, li l. J Med Chem. 2012 Dec 13;55(23):10540-50. doi: 10.1021/jm301159y. Epub 2012 Nov 19. J Med Chem. 2012. PMID: 23137303

4

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.

Gong X, Wang G, Ren J, Liu Z, Wang Z, Chen T, Yang X, Jiang X, Shen J, Jiang H, Aisa HA, Xu Y, Li J. Gong X, et al. Among authors: li j. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4944-7. doi: 10.1016/j.bmcl.2013.06.062. Epub 2013 Jun 29. Bioorg Med Chem Lett. 2013. PMID: 23867165

5

Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.

Xiamuxi H, Wang Z, Li J, Wang Y, Wu C, Yang F, Jiang X, Liu Y, Zhao Q, Chen W, Zhang J, Xie Y, Hu T, Xu M, Guo S, Akber Aisa H, He Y, Shen J. Xiamuxi H, et al. Among authors: li j. Bioorg Med Chem. 2017 Sep 1;25(17):4904-4916. doi: 10.1016/j.bmc.2017.07.040. Epub 2017 Jul 24. Bioorg Med Chem. 2017. PMID: 28774576

6

Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect.

Xu M, Wang Y, Yang F, Wu C, Wang Z, Ye B, Jiang X, Zhao Q, Li J, Liu Y, Zhang J, Tian G, He Y, Shen J, Jiang H. Xu M, et al. Among authors: li j. Eur J Med Chem. 2018 Feb 10;145:74-85. doi: 10.1016/j.ejmech.2017.12.099. Epub 2018 Jan 4. Eur J Med Chem. 2018. PMID: 29324345

7

Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs.

Xu M, Wang Y, Yang F, Wu C, Wang Z, Ye B, Jiang X, Zhao Q, Li J, Liu Y, Zhang J, Tian G, He Y, Shen J, Jiang H. Xu M, et al. Among authors: li j. Bioorg Med Chem Lett. 2018 Feb 15;28(4):606-611. doi: 10.1016/j.bmcl.2018.01.038. Epub 2018 Jan 31. Bioorg Med Chem Lett. 2018. PMID: 29395980

8

Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.

Yang F, Jiang X, Li J, Wang Y, Liu Y, Bi M, Wu C, Zhao Q, Chen W, Yin J, Zhang J, Xie Y, Hu T, Xu M, Guo S, Wang Z, He Y, Shen J. Yang F, et al. Among authors: li j. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3141-3147. doi: 10.1016/j.bmcl.2016.04.087. Epub 2016 Apr 30. Bioorg Med Chem Lett. 2016. PMID: 27173799

9

Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives.

Xia G, Li J, Peng A, Lai S, Zhang S, Shen J, Liu Z, Chen X, Ji R. Xia G, et al. Among authors: li j. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2790-4. doi: 10.1016/j.bmcl.2005.03.102. Bioorg Med Chem Lett. 2005. PMID: 15878277

10

The selectivity and potency of the new PDE5 inhibitor TPN729MA.

Wang Z, Zhu D, Yang X, Li J, Jiang X, Tian G, Terrett NK, Jin J, Wu H, He Q, Yang B, Shen J. Wang Z, et al. Among authors: li j. J Sex Med. 2013 Nov;10(11):2790-7. doi: 10.1111/jsm.12285. Epub 2013 Aug 12. J Sex Med. 2013. PMID: 23937247

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