Li H - Search Results

1

Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.

Hu E, Hong FT, Aral J, Long J, Piper DE, Poppe L, Andrews KL, Hager T, Davis C, Li H, Wong P, Gavva N, Shi L, Zhu DXD, Lehto SG, Xu C, Miranda LP. Hu E, et al. Among authors: li h. J Med Chem. 2021 Mar 25;64(6):3427-3438. doi: 10.1021/acs.jmedchem.0c01396. Epub 2021 Mar 15. J Med Chem. 2021. PMID: 33715378

2

Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity.

Miranda LP, Winters KA, Gegg CV, Patel A, Aral J, Long J, Zhang J, Diamond S, Guido M, Stanislaus S, Ma M, Li H, Rose MJ, Poppe L, Véniant MM. Miranda LP, et al. Among authors: li h. J Med Chem. 2008 May 8;51(9):2758-65. doi: 10.1021/jm701522b. Epub 2008 Apr 15. J Med Chem. 2008. PMID: 18412318

3

Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.

Miranda LP, Holder JR, Shi L, Bennett B, Aral J, Gegg CV, Wright M, Walker K, Doellgast G, Rogers R, Li H, Valladares V, Salyers K, Johnson E, Wild K. Miranda LP, et al. Among authors: li h. J Med Chem. 2008 Dec 25;51(24):7889-97. doi: 10.1021/jm8009298. J Med Chem. 2008. PMID: 19053766

4

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel.

Murray JK, Ligutti J, Liu D, Zou A, Poppe L, Li H, Andrews KL, Moyer BD, McDonough SI, Favreau P, Stöcklin R, Miranda LP. Murray JK, et al. Among authors: li h. J Med Chem. 2015 Mar 12;58(5):2299-314. doi: 10.1021/jm501765v. Epub 2015 Feb 19. J Med Chem. 2015. PMID: 25658507

5

Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.

Murray JK, Qian YX, Liu B, Elliott R, Aral J, Park C, Zhang X, Stenkilsson M, Salyers K, Rose M, Li H, Yu S, Andrews KL, Colombero A, Werner J, Gaida K, Sickmier EA, Miu P, Itano A, McGivern J, Gegg CV, Sullivan JK, Miranda LP. Murray JK, et al. Among authors: li h. J Med Chem. 2015 Sep 10;58(17):6784-802. doi: 10.1021/acs.jmedchem.5b00495. Epub 2015 Aug 31. J Med Chem. 2015. PMID: 26288216

6

Direct quantitative analysis of a 20 kDa PEGylated human calcitonin gene peptide antagonist in cynomolgus monkey serum using in-source CID and UPLC-MS/MS.

Li H, Rose MJ, Holder JR, Wright M, Miranda LP, James CA. Li H, et al. J Am Soc Mass Spectrom. 2011 Sep;22(9):1660-7. doi: 10.1007/s13361-011-0180-2. Epub 2011 Jun 23. J Am Soc Mass Spectrom. 2011. PMID: 21953269

7

A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.

Uppalapati M, Lee DJ, Mandal K, Li H, Miranda LP, Lowitz J, Kenney J, Adams JJ, Ault-Riché D, Kent SB, Sidhu SS. Uppalapati M, et al. Among authors: li h. ACS Chem Biol. 2016 Apr 15;11(4):1058-65. doi: 10.1021/acschembio.5b01006. Epub 2016 Feb 3. ACS Chem Biol. 2016. PMID: 26745345

8

Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species.

Foti RS, Biswas K, Aral J, Be X, Berry L, Cheng Y, Conner K, Falsey JR, Glaus C, Herberich B, Hickman D, Ikotun T, Li H, Long J, Huang L, Miranda LP, Murray J, Moyer B, Netirojjanakul C, Nixey TE, Sham K, Soto M, Tegley CM, Tran L, Wu B, Yin L, Rock DA. Foti RS, et al. Among authors: li h. Drug Metab Dispos. 2019 Oct;47(10):1111-1121. doi: 10.1124/dmd.119.087742. Epub 2019 Aug 6. Drug Metab Dispos. 2019. PMID: 31387871

9

Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS.

Li H, Rose MJ, Tran L, Zhang J, Miranda LP, James CA, Sasu BJ. Li H, et al. J Pharmacol Toxicol Methods. 2009 May-Jun;59(3):171-80. doi: 10.1016/j.vascn.2009.02.004. Epub 2009 Feb 28. J Pharmacol Toxicol Methods. 2009. PMID: 19258043

10

Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism.

Killion EA, Chen M, Falsey JR, Sivits G, Hager T, Atangan L, Helmering J, Lee J, Li H, Wu B, Cheng Y, Véniant MM, Lloyd DJ. Killion EA, et al. Among authors: li h. Nat Commun. 2020 Oct 5;11(1):4981. doi: 10.1038/s41467-020-18751-8. Nat Commun. 2020. PMID: 33020469 Free PMC article.

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