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Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene-edited human-induced pluripotent stem cell-derived cardiomyocytes and preclinical drug screening.
El-Battrawy I, Lan H, Cyganek L, Maywald L, Zhong R, Zhang F, Xu Q, Lee J, Duperrex E, Hierlemann A, Saguner AM, Duru F, Kovacs B, Huang M, Liao Z, Albers S, Müller J, Dinkel H, Rose L, Hohn A, Yang Z, Qiao L, Li Y, Lang S, Kleinsorge M, Mügge A, Aweimer A, Fan X, Diecke S, Akin I, Li G, Zhou X. El-Battrawy I, et al. Among authors: li y, li g. Clin Transl Med. 2021 Dec;11(12):e646. doi: 10.1002/ctm2.646. Clin Transl Med. 2021. PMID: 34954893 Free PMC article. No abstract available.
Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient.
Ma D, Liu Z, Loh LJ, Zhao Y, Li G, Liew R, Islam O, Wu J, Chung YY, Teo WS, Ching CK, Tan BY, Chong D, Ho KL, Lim P, Yong RYY, Panama BK, Kaplan AD, Bett GCL, Ware J, Bezzina CR, Verkerk AO, Cook SA, Rasmusson RL, Wei H. Ma D, et al. Among authors: li g. Sci Rep. 2018 Jul 26;8(1):11246. doi: 10.1038/s41598-018-29574-5. Sci Rep. 2018. PMID: 30050137 Free PMC article.
Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.
Buikema JW, Lee S, Goodyer WR, Maas RG, Chirikian O, Li G, Miao Y, Paige SL, Lee D, Wu H, Paik DT, Rhee S, Tian L, Galdos FX, Puluca N, Beyersdorf B, Hu J, Beck A, Venkamatran S, Swami S, Wijnker P, Schuldt M, Dorsch LM, van Mil A, Red-Horse K, Wu JY, Geisen C, Hesse M, Serpooshan V, Jovinge S, Fleischmann BK, Doevendans PA, van der Velden J, Garcia KC, Wu JC, Sluijter JPG, Wu SM. Buikema JW, et al. Among authors: li g. Cell Stem Cell. 2020 Jul 2;27(1):50-63.e5. doi: 10.1016/j.stem.2020.06.001. Cell Stem Cell. 2020. PMID: 32619518 Free PMC article.
Mammalian Heart Regeneration: The Race to the Finish Line.
Doppler SA, Deutsch MA, Serpooshan V, Li G, Dzilic E, Lange R, Krane M, Wu SM. Doppler SA, et al. Among authors: li g. Circ Res. 2017 Feb 17;120(4):630-632. doi: 10.1161/CIRCRESAHA.116.310051. Circ Res. 2017. PMID: 28209796 Free PMC article.
CRISPR/Cas9-based targeting of fluorescent reporters to human iPSCs to isolate atrial and ventricular-specific cardiomyocytes.
Chirikian O, Goodyer WR, Dzilic E, Serpooshan V, Buikema JW, McKeithan W, Wu H, Li G, Lee S, Merk M, Galdos F, Beck A, Ribeiro AJS, Paige S, Mercola M, Wu JC, Pruitt BL, Wu SM. Chirikian O, et al. Among authors: li g. Sci Rep. 2021 Feb 4;11(1):3026. doi: 10.1038/s41598-021-81860-x. Sci Rep. 2021. PMID: 33542270 Free PMC article.
Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss.
Sturzu AC, Rajarajan K, Passer D, Plonowska K, Riley A, Tan TC, Sharma A, Xu AF, Engels MC, Feistritzer R, Li G, Selig MK, Geissler R, Robertson KD, Scherrer-Crosbie M, Domian IJ, Wu SM. Sturzu AC, et al. Among authors: li g. Circulation. 2015 Jul 14;132(2):109-21. doi: 10.1161/CIRCULATIONAHA.114.011490. Epub 2015 May 20. Circulation. 2015. PMID: 25995316 Free PMC article.
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