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Activation of neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain.
Tassou A, Thouaye M, Gilabert D, Jouvenel A, Leyris JP, Sonrier C, Diouloufet L, Mechaly I, Mallié S, Bertin J, Chentouf M, Neiveyans M, Pugnière M, Martineau P, Robert B, Capdevila X, Valmier J, Rivat C. Tassou A, et al. Among authors: leyris jp. Prog Neurobiol. 2023 Mar;222:102405. doi: 10.1016/j.pneurobio.2023.102405. Epub 2023 Jan 13. Prog Neurobiol. 2023. PMID: 36646299 Free article.
High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators.
Hany R, Leyris JP, Bret G, Mallié S, Sar C, Thouaye M, Hamze A, Provot O, Sokoloff P, Valmier J, Villa P, Rognan D. Hany R, et al. Among authors: leyris jp. ACS Chem Biol. 2022 Mar 18;17(3):709-722. doi: 10.1021/acschembio.2c00048. Epub 2022 Feb 28. ACS Chem Biol. 2022. PMID: 35227060 Free article.
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice.
Rivat C, Sar C, Mechaly I, Leyris JP, Diouloufet L, Sonrier C, Philipson Y, Lucas O, Mallié S, Jouvenel A, Tassou A, Haton H, Venteo S, Pin JP, Trinquet E, Charrier-Savournin F, Mezghrani A, Joly W, Mion J, Schmitt M, Pattyn A, Marmigère F, Sokoloff P, Carroll P, Rognan D, Valmier J. Rivat C, et al. Among authors: leyris jp. Nat Commun. 2018 Mar 12;9(1):1042. doi: 10.1038/s41467-018-03496-2. Nat Commun. 2018. PMID: 29531216 Free PMC article.
Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.
M'Kadmi C, Leyris JP, Onfroy L, Galés C, Saulière A, Gagne D, Damian M, Mary S, Maingot M, Denoyelle S, Verdié P, Fehrentz JA, Martinez J, Banères JL, Marie J. M'Kadmi C, et al. Among authors: leyris jp. J Biol Chem. 2015 Nov 6;290(45):27021-27039. doi: 10.1074/jbc.M115.659250. Epub 2015 Sep 11. J Biol Chem. 2015. PMID: 26363071 Free PMC article.
Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex.
Damian M, Mary S, Maingot M, M'Kadmi C, Gagne D, Leyris JP, Denoyelle S, Gaibelet G, Gavara L, Garcia de Souza Costa M, Perahia D, Trinquet E, Mouillac B, Galandrin S, Galès C, Fehrentz JA, Floquet N, Martinez J, Marie J, Banères JL. Damian M, et al. Among authors: leyris jp. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1601-6. doi: 10.1073/pnas.1414618112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605885 Free PMC article.
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