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Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.
Cogo S, Tomkins JE, Vavouraki N, Giusti V, Forcellato F, Franchin C, Tessari I, Arrigoni G, Cendron L, Manzoni C, Civiero L, Lewis PA, Greggio E. Cogo S, et al. Among authors: lewis pa. Neurobiol Dis. 2022 Nov;174:105858. doi: 10.1016/j.nbd.2022.105858. Epub 2022 Sep 9. Neurobiol Dis. 2022. PMID: 36096339 Free article.
Inhibition of LRRK2 kinase activity stimulates macroautophagy.
Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar MPM, Plun-Favreau H, Giunti P, Tooze SA, Bandopadhyay R, Lewis PA. Manzoni C, et al. Among authors: lewis pa. Biochim Biophys Acta. 2013 Dec;1833(12):2900-2910. doi: 10.1016/j.bbamcr.2013.07.020. Epub 2013 Aug 1. Biochim Biophys Acta. 2013. PMID: 23916833 Free PMC article.
Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation.
Manzoni C, Mamais A, Dihanich S, McGoldrick P, Devine MJ, Zerle J, Kara E, Taanman JW, Healy DG, Marti-Masso JF, Schapira AH, Plun-Favreau H, Tooze S, Hardy J, Bandopadhyay R, Lewis PA. Manzoni C, et al. Among authors: lewis pa. Biochem Biophys Res Commun. 2013 Nov 29;441(4):862-6. doi: 10.1016/j.bbrc.2013.10.159. Epub 2013 Nov 6. Biochem Biophys Res Commun. 2013. PMID: 24211199 Free PMC article.
Computational analysis of the LRRK2 interactome.
Manzoni C, Denny P, Lovering RC, Lewis PA. Manzoni C, et al. Among authors: lewis pa. PeerJ. 2015 Feb 19;3:e778. doi: 10.7717/peerj.778. eCollection 2015. PeerJ. 2015. PMID: 25737818 Free PMC article.
366 results