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Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability.
Abbott KL, Ali A, Reinfeld BI, Deik A, Subudhi S, Landis MD, Hongo RA, Young KL, Kunchok T, Nabel CS, Crowder KD, Kent JR, Madariaga MLL, Jain RK, Beckermann KE, Lewis CA, Clish CB, Muir A, Rathmell WK, Rathmell JC, Vander Heiden MG. Abbott KL, et al. Among authors: lewis ca. bioRxiv [Preprint]. 2024 Apr 8:2023.12.24.573250. doi: 10.1101/2023.12.24.573250. bioRxiv. 2024. PMID: 38187626 Free PMC article. Preprint.
Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Linder SJ, Bernasocchi T, Martínez-Pastor B, Sullivan KD, Galbraith MD, Lewis CA, Ferrer CM, Boon R, Silveira GG, Cho HM, Vidoudez C, Shroff S, Oliveira-Costa JP, Ross KN, Massri R, Matoba Y, Kim E, Rueda BR, Stott SL, Gottlieb E, Espinosa JM, Mostoslavsky R. Linder SJ, et al. Among authors: lewis ca. Nat Metab. 2023 Dec;5(12):2131-2147. doi: 10.1038/s42255-023-00919-3. Epub 2023 Nov 13. Nat Metab. 2023. PMID: 37957387
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Abbott KL, Ali A, Casalena D, Do BT, Ferreira R, Cheah JH, Soule CK, Deik A, Kunchok T, Schmidt DR, Renner S, Honeder SE, Wu M, Chan SH, Tseyang T, Stoltzfus AT, Michel SLJ, Greaves D, Hsu PP, Ng CW, Zhang CJ, Farsidjani A, Kent JR, Madariaga MLL, Gramatikov IMT, Matheson NJ, Lewis CA, Clish CB, Rees MG, Roth JA, Griner LM, Muir A, Auld DS, Vander Heiden MG. Abbott KL, et al. Among authors: lewis ca. Cell Chem Biol. 2023 Sep 21;30(9):1156-1168.e7. doi: 10.1016/j.chembiol.2023.08.007. Epub 2023 Sep 8. Cell Chem Biol. 2023. PMID: 37689063
Early Clinical Development of Lufotrelvir as a Potential Therapy for COVID-19.
Allais C, Bernhardson D, Brown AR, Chinigo GM, Desrosiers JN, DiRico KJ, Hotham I, Jones BP, Kulkarni SA, Lewis CA, Lira R, Loach RP, Morse PD, Mousseau JJ, Perry MA, Peng Z, Place DW, Rane AM, Samp L, Singer RA, Wang Z, Weisenburger GA, Yayla HG, Zanghi JM. Allais C, et al. Among authors: lewis ca. Org Process Res Dev. 2023 Feb 3:acs.oprd.2c00375. doi: 10.1021/acs.oprd.2c00375. Online ahead of print. Org Process Res Dev. 2023. PMID: 37552749 Review.
435 results