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FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade.
De Rossi P, Lewis AJ, Furrer J, De Vos L, Demeter T, Zbinden A, Zhong W, Wiersma VI, Scialo C, Weber J, Guo Z, Scaramuzza S, Di Fabrizio M, Böing C, Castaño-Díez D, Al-Amoudi A, Pérez-Berlanga M, Lashley T, Stahlberg H, Polymenidou M. De Rossi P, et al. Among authors: lewis aj. EMBO Rep. 2021 Dec 6;22(12):e53877. doi: 10.15252/embr.202153877. Epub 2021 Nov 22. EMBO Rep. 2021. PMID: 34806807 Free PMC article.
TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.
Laferrière F, Maniecka Z, Pérez-Berlanga M, Hruska-Plochan M, Gilhespy L, Hock EM, Wagner U, Afroz T, Boersema PJ, Barmettler G, Foti SC, Asi YT, Isaacs AM, Al-Amoudi A, Lewis A, Stahlberg H, Ravits J, De Giorgi F, Ichas F, Bezard E, Picotti P, Lashley T, Polymenidou M. Laferrière F, et al. Nat Neurosci. 2019 Jan;22(1):65-77. doi: 10.1038/s41593-018-0294-y. Epub 2018 Dec 17. Nat Neurosci. 2019. PMID: 30559480
Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles.
Navarro PP, Genoud C, Castaño-Díez D, Graff-Meyer A, Lewis AJ, de Gier Y, Lauer ME, Britschgi M, Bohrmann B, Frank S, Hench J, Schweighauser G, Rozemuller AJM, van de Berg WDJ, Stahlberg H, Shahmoradian SH. Navarro PP, et al. Among authors: lewis aj. Sci Rep. 2018 Dec 21;8(1):18046. doi: 10.1038/s41598-018-36223-4. Sci Rep. 2018. PMID: 30575769 Free PMC article.
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.
Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP, Castaño-Díez D, Schweighauser G, Graff-Meyer A, Goldie KN, Sütterlin R, Huisman E, Ingrassia A, Gier Y, Rozemuller AJM, Wang J, Paepe A, Erny J, Staempfli A, Hoernschemeyer J, Großerüschkamp F, Niedieker D, El-Mashtoly SF, Quadri M, Van IJcken WFJ, Bonifati V, Gerwert K, Bohrmann B, Frank S, Britschgi M, Stahlberg H, Van de Berg WDJ, Lauer ME. Shahmoradian SH, et al. Among authors: lewis aj. Nat Neurosci. 2019 Jul;22(7):1099-1109. doi: 10.1038/s41593-019-0423-2. Epub 2019 Jun 24. Nat Neurosci. 2019. PMID: 31235907
Alterations in Sub-Axonal Architecture Between Normal Aging and Parkinson's Diseased Human Brains Using Label-Free Cryogenic X-ray Nanotomography.
Tran HT, Tsai EHR, Lewis AJ, Moors T, Bol JGJM, Rostami I, Diaz A, Jonker AJ, Guizar-Sicairos M, Raabe J, Stahlberg H, van de Berg WDJ, Holler M, Shahmoradian SH. Tran HT, et al. Among authors: lewis aj. Front Neurosci. 2020 Nov 25;14:570019. doi: 10.3389/fnins.2020.570019. eCollection 2020. Front Neurosci. 2020. PMID: 33324142 Free PMC article.
The Operating Room Rotation.
Lewis AJ. Lewis AJ. Radiol Technol. 2024 May;95(5):388-389. Radiol Technol. 2024. PMID: 38719551 No abstract available.
560 results