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Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.
Lewis AC, Pope VS, Tea MN, Li M, Nwosu GO, Nguyen TM, Wallington-Beddoe CT, Moretti PAB, Anderson D, Creek DJ, Costabile M, Ali SR, Thompson-Peach CAL, Dredge BK, Bert AG, Goodall GJ, Ekert PG, Brown AL, D'Andrea R, Robinson N, Pitman MR, Thomas D, Ross DM, Gliddon BL, Powell JA, Pitson SM. Lewis AC, et al. Blood. 2022 Jun 30;139(26):3737-3751. doi: 10.1182/blood.2021013277. Blood. 2022. PMID: 35443029 Free PMC article.
Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia.
Powell JA, Lewis AC, Zhu W, Toubia J, Pitman MR, Wallington-Beddoe CT, Moretti PA, Iarossi D, Samaraweera SE, Cummings N, Ramshaw HS, Thomas D, Wei AH, Lopez AF, D'Andrea RJ, Lewis ID, Pitson SM. Powell JA, et al. Among authors: lewis id, lewis ac. Blood. 2017 Feb 9;129(6):771-782. doi: 10.1182/blood-2016-06-720433. Epub 2016 Dec 12. Blood. 2017. PMID: 27956387 Free PMC article.
Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models.
Morrish E, Copeland A, Moujalled DM, Powell JA, Silke N, Lin A, Jarman KE, Sandow JJ, Ebert G, Mackiewicz L, Beach JA, Christie EL, Lewis AC, Pomilio G, Fischer KC, MacPherson L, Bowtell DDL, Webb AI, Pellegrini M, Dawson MA, Pitson SM, Wei AH, Silke J, Brumatti G. Morrish E, et al. Among authors: lewis ac. Blood Adv. 2020 Oct 27;4(20):5062-5077. doi: 10.1182/bloodadvances.2020001576. Blood Adv. 2020. PMID: 33080008 Free PMC article.
ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.
Boyle ST, Poltavets V, Kular J, Pyne NT, Sandow JJ, Lewis AC, Murphy KJ, Kolesnikoff N, Moretti PAB, Tea MN, Tergaonkar V, Timpson P, Pitson SM, Webb AI, Whitfield RJ, Lopez AF, Kochetkova M, Samuel MS. Boyle ST, et al. Among authors: lewis ac. Nat Cell Biol. 2020 Jul;22(7):882-895. doi: 10.1038/s41556-020-0523-y. Epub 2020 May 25. Nat Cell Biol. 2020. PMID: 32451439
Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism.
Boyle ST, Poltavets V, Kular J, Pyne NT, Sandow JJ, Lewis AC, Murphy KJ, Kolesnikoff N, Moretti PAB, Tea MN, Tergaonkar V, Timpson P, Pitson SM, Webb AI, Whitfield RJ, Lopez AF, Kochetkova M, Samuel MS. Boyle ST, et al. Among authors: lewis ac. Nat Cell Biol. 2020 Jul;22(7):908. doi: 10.1038/s41556-020-0539-3. Nat Cell Biol. 2020. PMID: 32499616
160 results