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Touch sensation requires the mechanically gated ion channel ELKIN1.
Chakrabarti S, Klich JD, Khallaf MA, Hulme AJ, Sánchez-Carranza O, Baran ZM, Rossi A, Huang AT, Pohl T, Fleischer R, Fürst C, Hammes A, Bégay V, Hörnberg H, Finol-Urdaneta RK, Poole K, Dottori M, Lewin GR. Chakrabarti S, et al. Among authors: lewin gr. Science. 2024 Mar;383(6686):992-998. doi: 10.1126/science.adl0495. Epub 2024 Feb 29. Science. 2024. PMID: 38422143
TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration.
Patkunarajah A, Stear JH, Moroni M, Schroeter L, Blaszkiewicz J, Tearle JL, Cox CD, Fürst C, Sánchez-Carranza O, Ocaña Fernández MDÁ, Fleischer R, Eravci M, Weise C, Martinac B, Biro M, Lewin GR, Poole K. Patkunarajah A, et al. Among authors: lewin gr. Elife. 2020 Apr 1;9:e53308. doi: 10.7554/eLife.53308. Elife. 2020. PMID: 32228863 Free PMC article.
Sensory mechanotransduction at membrane-matrix interfaces.
Poole K, Moroni M, Lewin GR. Poole K, et al. Among authors: lewin gr. Pflugers Arch. 2015 Jan;467(1):121-32. doi: 10.1007/s00424-014-1563-6. Epub 2014 Jul 2. Pflugers Arch. 2015. PMID: 24981693 Free PMC article. Review.
Voltage gating of mechanosensitive PIEZO channels.
Moroni M, Servin-Vences MR, Fleischer R, Sánchez-Carranza O, Lewin GR. Moroni M, et al. Among authors: lewin gr. Nat Commun. 2018 Mar 15;9(1):1096. doi: 10.1038/s41467-018-03502-7. Nat Commun. 2018. PMID: 29545531 Free PMC article.
Rapid molecular evolution of pain insensitivity in multiple African rodents.
Eigenbrod O, Debus KY, Reznick J, Bennett NC, Sánchez-Carranza O, Omerbašić D, Hart DW, Barker AJ, Zhong W, Lutermann H, Katandukila JV, Mgode G, Park TJ, Lewin GR. Eigenbrod O, et al. Among authors: lewin gr. Science. 2019 May 31;364(6443):852-859. doi: 10.1126/science.aau0236. Science. 2019. PMID: 31147513
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR. Wetzel C, et al. Among authors: lewin gr. Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12. Nat Neurosci. 2017. PMID: 27941788
Mechanoelectrical transduction in chondrocytes.
Servin-Vences MR, Richardson J, Lewin GR, Poole K. Servin-Vences MR, et al. Among authors: lewin gr. Clin Exp Pharmacol Physiol. 2018 May;45(5):481-488. doi: 10.1111/1440-1681.12917. Epub 2018 Feb 19. Clin Exp Pharmacol Physiol. 2018. PMID: 29359488 Review.
178 results