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Page 1
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.
Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K. Felszeghy S, et al. Among authors: levonen al. Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14. Redox Biol. 2019. PMID: 30253279 Free PMC article.
PI3Kβ inhibition enhances ALK-inhibitor sensitivity in ALK-rearranged lung cancer.
Talwelkar SS, Mäyränpää MI, Schüler J, Linnavirta N, Hemmes A, Adinolfi S, Kankainen M, Sommergruber W, Levonen AL, Räsänen J, Knuuttila A, Verschuren EW, Wennerberg K. Talwelkar SS, et al. Among authors: levonen al. Mol Oncol. 2023 May;17(5):747-764. doi: 10.1002/1878-0261.13342. Epub 2023 Jan 25. Mol Oncol. 2023. PMID: 36423211 Free PMC article.
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen AL, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J, Laakso M. Pirinen E, et al. Among authors: levonen al. Mol Cell Biol. 2007 Jul;27(13):4953-67. doi: 10.1128/MCB.02034-06. Epub 2007 May 7. Mol Cell Biol. 2007. PMID: 17485446 Free PMC article.
Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.
Kanninen K, Malm TM, Jyrkkänen HK, Goldsteins G, Keksa-Goldsteine V, Tanila H, Yamamoto M, Ylä-Herttuala S, Levonen AL, Koistinaho J. Kanninen K, et al. Among authors: levonen al. Mol Cell Neurosci. 2008 Nov;39(3):302-13. doi: 10.1016/j.mcn.2008.07.010. Epub 2008 Jul 29. Mol Cell Neurosci. 2008. PMID: 18706502
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease.
Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. Kanninen K, et al. Among authors: levonen al. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16505-10. doi: 10.1073/pnas.0908397106. Epub 2009 Sep 10. Proc Natl Acad Sci U S A. 2009. PMID: 19805328 Free PMC article.
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL. Leinonen HM, et al. Among authors: levonen al. Cancer Res. 2012 Dec 1;72(23):6227-35. doi: 10.1158/0008-5472.CAN-12-1166. Epub 2012 Oct 4. Cancer Res. 2012. PMID: 23041549
The absence of macrophage Nrf2 promotes early atherogenesis.
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. Ruotsalainen AK, et al. Among authors: levonen al. Cardiovasc Res. 2013 Apr 1;98(1):107-15. doi: 10.1093/cvr/cvt008. Epub 2013 Jan 22. Cardiovasc Res. 2013. PMID: 23341579
Does Nrf2 gene transfer facilitate recovery after contusion spinal cord injury?
Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Ylä-Herttuala S, Malm T, Kanninen K, Koistinaho J. Pomeshchik Y, et al. Among authors: levonen al. Antioxid Redox Signal. 2014 Mar 10;20(8):1313-23. doi: 10.1089/ars.2013.5453. Epub 2013 Aug 20. Antioxid Redox Signal. 2014. PMID: 23841575
Nrf2 regulates neurogenesis and protects neural progenitor cells against Aβ toxicity.
Kärkkäinen V, Pomeshchik Y, Savchenko E, Dhungana H, Kurronen A, Lehtonen S, Naumenko N, Tavi P, Levonen AL, Yamamoto M, Malm T, Magga J, Kanninen KM, Koistinaho J. Kärkkäinen V, et al. Among authors: levonen al. Stem Cells. 2014 Jul;32(7):1904-16. doi: 10.1002/stem.1666. Stem Cells. 2014. PMID: 24753106
98 results