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Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension.
Di Pietro P, Carrizzo A, Sommella E, Oliveti M, Iacoviello L, Di Castelnuovo A, Acernese F, Damato A, De Lucia M, Merciai F, Iesu P, Venturini E, Izzo R, Trimarco V, Ciccarelli M, Giugliano G, Carnevale R, Cammisotto V, Migliarino S, Virtuoso N, Strianese A, Izzo V, Campiglia P, Ciaglia E, Levkau B, Puca AA, Vecchione C. Di Pietro P, et al. Among authors: levkau b. J Clin Invest. 2022 Feb 1;132(3):e146343. doi: 10.1172/JCI146343. J Clin Invest. 2022. PMID: 35104805 Free PMC article.
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.
Nofer JR, van der Giet M, Tölle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Gödecke A, Ishii I, Kleuser B, Schäfers M, Fobker M, Zidek W, Assmann G, Chun J, Levkau B. Nofer JR, et al. Among authors: levkau b. J Clin Invest. 2004 Feb;113(4):569-81. doi: 10.1172/JCI18004. J Clin Invest. 2004. PMID: 14966566 Free PMC article.
Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.
Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J. Walter DH, et al. Among authors: levkau b. Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):275-82. doi: 10.1161/01.ATV.0000254669.12675.70. Epub 2006 Dec 7. Arterioscler Thromb Vasc Biol. 2007. PMID: 17158356
Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy.
Keul P, Polzin A, Kaiser K, Gräler M, Dannenberg L, Daum G, Heusch G, Levkau B. Keul P, et al. Among authors: levkau b. FASEB J. 2019 Jan;33(1):1482-1495. doi: 10.1096/fj.201801245R. Epub 2018 Aug 21. FASEB J. 2019. PMID: 30130432
., Kaiser, K., Graler, M., Dannenberg, L., Daum, G., Heusch, G., Levkau, B. Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfu …
., Kaiser, K., Graler, M., Dannenberg, L., Daum, G., Heusch, G., Levkau, B. Potent anti-inflammatory properties of HDL in vasc …
165 results