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A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Pérez-Vargas J, Worrall LJ, Olmstead AD, Ton AT, Lee J, Villanueva I, Thompson CAH, Dudek S, Ennis S, Smith JR, Shapira T, De Guzman J, Gang S, Ban F, Vuckovic M, Bielecki M, Kovacic S, Kenward C, Hong CY, Gordon DG, Levett PN, Krajden M, Leduc R, Boudreault PL, Niikura M, Paetzel M, Young RN, Cherkasov A, Strynadka NCJ, Jean F. Pérez-Vargas J, et al. Among authors: levett pn. Emerg Microbes Infect. 2023 Dec;12(2):2246594. doi: 10.1080/22221751.2023.2246594. Emerg Microbes Infect. 2023. PMID: 37555275 Free PMC article.
Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics.
Pérez-Vargas J, Shapira T, Olmstead AD, Villanueva I, Thompson CAH, Ennis S, Gao G, De Guzman J, Williams DE, Wang M, Chin A, Bautista-Sánchez D, Agafitei O, Levett P, Xie X, Nuzzo G, Freire VF, Quintana-Bulla JI, Bernardi DI, Gubiani JR, Suthiphasilp V, Raksat A, Meesakul P, Polbuppha I, Cheenpracha S, Jaidee W, Kanokmedhakul K, Yenjai C, Chaiyosang B, Teles HL, Manzo E, Fontana A, Leduc R, Boudreault PL, Berlinck RGS, Laphookhieo S, Kanokmedhakul S, Tietjen I, Cherkasov A, Krajden M, Nabi IR, Niikura M, Shi PY, Andersen RJ, Jean F. Pérez-Vargas J, et al. Antiviral Res. 2023 Jan;209:105484. doi: 10.1016/j.antiviral.2022.105484. Epub 2022 Dec 8. Antiviral Res. 2023. PMID: 36503013 Free PMC article.
Corrigendum to "Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics" "Antiviral Research 209 (2023)/105484".
Perez-Vargas J, Shapira T, Olmstead AD, Villanueva I, Thompson CAH, Ennis S, Gao G, De Guzman J, Williams DE, Wang M, Chin A, Bautista-Sanchez D, Agafitei O, Levett P, Xie X, Nuzzo G, Freire VF, Quintana-Bulla JI, Bernardi DI, Gubiani JR, Suthiphasilp V, Raksat A, Meesakul P, Polbuppha I, Cheenpracha S, Jaidee W, Kanokmedhakul K, Yenjai C, Chaiyosang B, Teles HL, Manzo E, Fontana A, Leduc R, Boudreault PL, Berlinck RGS, Laphookhieo S, Kanokmedhakul S, Tietjen I, Cherkasov A, Krajden M, Nabi IR, Niikura M, Shi PY, Andersen RJ, Jean F. Perez-Vargas J, et al. Antiviral Res. 2023 May;213:105577. doi: 10.1016/j.antiviral.2023.105577. Epub 2023 Mar 30. Antiviral Res. 2023. PMID: 37002158 Free PMC article. No abstract available.
Canadian SARS-CoV-2 serological survey using antenatal serum samples: a retrospective seroprevalence study.
Atkinson A, Albert A, McClymont E, Andrade J, Beach L, Bolotin S, Boucoiran I, Bullard J, Charlton C, Crane J, Dougan S, Forest JC, German GJ, Giguère Y, Girouard G, Hankins C, Krajden M, Lang A, Levett P, Minion J, Neudorf C, Poliquin V, Robinson JL, Scott H, Stein DR, Tran V, Zahariadis G, Zhou HY, Money D; Antenatal Serostudies Team. Atkinson A, et al. CMAJ Open. 2023 Apr 4;11(2):E305-E313. doi: 10.9778/cmajo.20220045. Print 2023 Mar-Apr. CMAJ Open. 2023. PMID: 37015743 Free PMC article.
Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated Individuals.
Grunau B, Prusinkiewicz M, Asamoah-Boaheng M, Golding L, Lavoie PM, Petric M, Levett PN, Haig S, Barakauskas V, Karim ME, Jassem AN, Drews SJ, Sediqi S, Goldfarb DM. Grunau B, et al. Among authors: levett pn. Microbiol Spectr. 2022 Oct 26;10(5):e0131522. doi: 10.1128/spectrum.01315-22. Epub 2022 Sep 19. Microbiol Spectr. 2022. PMID: 36121252 Free PMC article.
Performance comparison of micro-neutralization assays based on surrogate SARS-CoV-2 and WT SARS-CoV-2 in assessing virus-neutralizing capacity of anti-SARS-CoV-2 antibodies.
Sekirov I, Petric M, Carruthers E, Lawrence D, Pidduck T, Kustra J, Laley J, Lee MK, Chahil N, Mak A, Levett PN, Mendoza E, Wood H, Drebot M, Krajden M, Morshed M. Sekirov I, et al. Among authors: levett pn. Access Microbiol. 2021 Aug 26;3(8):000257. doi: 10.1099/acmi.0.000257. eCollection 2021. Access Microbiol. 2021. PMID: 34888485 Free PMC article.
Evaluation of commercial SARS-CoV-2 serological assays in Canadian public health laboratories.
Stein DR, Osiowy C, Gretchen A, Thorlacius L, Fudge D, Lang A, Sekirov I, Morshed M, Levett PN, Tran V, Kus JV, Gubbay J, Mohan V, Charlton C, Kanji JN, Tipples G, Serhir B, Therrien C, Roger M, Jiao L, Zahariadis G, Needle R, Gilbert L, Desnoyers G, Garceau R, Bouhtiauy I, Longtin J, El-Gabalawy N, Dibernardo A, Lindsay LR, Drebot M; Canadian Public Health Laboratory Network (CPHLN) Serology Task Force. Stein DR, et al. Among authors: levett pn. Diagn Microbiol Infect Dis. 2021 Nov;101(3):115412. doi: 10.1016/j.diagmicrobio.2021.115412. Epub 2021 Apr 24. Diagn Microbiol Infect Dis. 2021. PMID: 34425450 Free PMC article.
181 results