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IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
Tan Y, Mosallanejad K, Zhang Q, O'Brien S, Clements M, Perper S, Wilson S, Chaulagain S, Wang J, Abdalla M, Al-Saidi H, Butt D, Clabbers A, Ofori K, Dillon B, Harvey B, Memmott J, Negron C, Winarta D, Tan C, Biswas A, Dong F, Morales-Tirado V, Lu X, Singh G, White M, Ashley S, Knight H, Westmoreland S, Phillips L, Carr T, Reinke-Breen L, Singh R, Xu J, Wu K, Rinaldi L, Stoll B, He YD, Hazelwood L, Karman J, McCluskey A, Stine W, Correia I, Gauld S, Levesque MC, Veldman G, Hubeau C, Radstake T, Sadhukhan R, Fiebiger E. Tan Y, et al. Among authors: levesque mc. Front Immunol. 2024 Feb 22;15:1293883. doi: 10.3389/fimmu.2024.1293883. eCollection 2024. Front Immunol. 2024. PMID: 38455057 Free PMC article.
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bowel disease.
Zhu Q, Korenfeld D, Suarez-Fueyo A, Graham S, Jin L, Punit S, Duffy R, Puri M, Caruso A, Hu C, Tian Y, McRae BL, Kamath R, Phillips L, Schwartz-Sterman AJ, Westmoreland S, Cao X, Levesque MC, Bi Y, Paez-Cortez J, Goenka R. Zhu Q, et al. Among authors: levesque mc. Mucosal Immunol. 2022 Jun;15(6):1338-1349. doi: 10.1038/s41385-022-00577-w. Epub 2022 Nov 13. Mucosal Immunol. 2022. PMID: 36372810 Free article.
Diminished cytokine-induced Jak/STAT signaling is associated with rheumatoid arthritis and disease activity.
Ptacek J, Hawtin RE, Sun D, Louie B, Evensen E, Mittleman BB, Cesano A, Cavet G, Bingham CO 3rd, Cofield SS, Curtis JR, Danila MI, Raman C, Furie RA, Genovese MC, Robinson WH, Levesque MC, Moreland LW, Nigrovic PA, Shadick NA, O'Dell JR, Thiele GM, Clair EWS, Striebich CC, Hale MB, Khalili H, Batliwalla F, Aranow C, Mackay M, Diamond B, Nolan GP, Gregersen PK, Bridges SL Jr. Ptacek J, et al. Among authors: levesque mc. PLoS One. 2021 Jan 14;16(1):e0244187. doi: 10.1371/journal.pone.0244187. eCollection 2021. PLoS One. 2021. PMID: 33444321 Free PMC article.
New Hampshire, USA.
Levesque MC. Levesque MC. Lancet Psychiatry. 2020 Dec;7(12):1020. doi: 10.1016/S2215-0366(20)30472-7. Lancet Psychiatry. 2020. PMID: 33220198 No abstract available.
A Phase II Trial of Lutikizumab, an Anti-Interleukin-1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis.
Fleischmann RM, Bliddal H, Blanco FJ, Schnitzer TJ, Peterfy C, Chen S, Wang L, Feng S, Conaghan PG, Berenbaum F, Pelletier JP, Martel-Pelletier J, Vaeterlein O, Kaeley GS, Liu W, Kosloski MP, Levy G, Zhang L, Medema JK, Levesque MC. Fleischmann RM, et al. Among authors: levesque mc. Arthritis Rheumatol. 2019 Jul;71(7):1056-1069. doi: 10.1002/art.40840. Epub 2019 Jun 7. Arthritis Rheumatol. 2019. PMID: 30653843 Free article. Clinical Trial.
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