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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J. Vince JE, et al. Among authors: leverkus m. Cell. 2007 Nov 16;131(4):682-93. doi: 10.1016/j.cell.2007.10.037. Cell. 2007. PMID: 18022363 Free article.
RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer.
Schneider AT, Gautheron J, Feoktistova M, Roderburg C, Loosen SH, Roy S, Benz F, Schemmer P, Büchler MW, Nachbur U, Neumann UP, Tolba R, Luedde M, Zucman-Rossi J, Panayotova-Dimitrova D, Leverkus M, Preisinger C, Tacke F, Trautwein C, Longerich T, Vucur M, Luedde T. Schneider AT, et al. Among authors: leverkus m. Cancer Cell. 2017 Jan 9;31(1):94-109. doi: 10.1016/j.ccell.2016.11.009. Epub 2016 Dec 22. Cancer Cell. 2017. PMID: 28017612 Free article.
NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.
Diessenbacher P, Hupe M, Sprick MR, Kerstan A, Geserick P, Haas TL, Wachter T, Neumann M, Walczak H, Silke J, Leverkus M. Diessenbacher P, et al. Among authors: leverkus m. J Invest Dermatol. 2008 May;128(5):1134-47. doi: 10.1038/sj.jid.5701141. Epub 2007 Nov 8. J Invest Dermatol. 2008. PMID: 17989734 Free article.
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Taraborrelli L, Peltzer N, Montinaro A, Kupka S, Rieser E, Hartwig T, Sarr A, Darding M, Draber P, Haas TL, Akarca A, Marafioti T, Pasparakis M, Bertin J, Gough PJ, Bouillet P, Strasser A, Leverkus M, Silke J, Walczak H. Taraborrelli L, et al. Among authors: leverkus m. Nat Commun. 2018 Sep 25;9(1):3910. doi: 10.1038/s41467-018-06155-8. Nat Commun. 2018. PMID: 30254289 Free PMC article.
Fas/CD95-induced chemokines can serve as "find-me" signals for apoptotic cells.
Cullen SP, Henry CM, Kearney CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, Martin SJ. Cullen SP, et al. Among authors: leverkus m. Mol Cell. 2013 Mar 28;49(6):1034-48. doi: 10.1016/j.molcel.2013.01.025. Epub 2013 Feb 21. Mol Cell. 2013. PMID: 23434371 Free article.
143 results