Leung KK - Search Results

1

The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.

Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG 3rd, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD Jr, Mullins RD, Eyquem J, Wells JA, Wiita AP. Ferguson ID, et al. Among authors: leung kk. Nat Commun. 2022 Jul 15;13(1):4121. doi: 10.1038/s41467-022-31810-6. Nat Commun. 2022. PMID: 35840578 Free PMC article.

2

Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif.

Mou Y, Zhou XX, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA. Mou Y, et al. J Am Chem Soc. 2018 Dec 5;140(48):16615-16624. doi: 10.1021/jacs.8b08402. Epub 2018 Nov 19. J Am Chem Soc. 2018. PMID: 30398859

3

Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome.

Leung KK, Nguyen A, Shi T, Tang L, Ni X, Escoubet L, MacBeth KJ, DiMartino J, Wells JA. Leung KK, et al. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):695-700. doi: 10.1073/pnas.1813666116. Epub 2018 Dec 24. Proc Natl Acad Sci U S A. 2019. PMID: 30584089 Free PMC article.

4

Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling.

Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ. Wei J, et al. Mol Cell Proteomics. 2020 Feb;19(2):294-307. doi: 10.1074/mcp.RA119.001785. Epub 2019 Dec 2. Mol Cell Proteomics. 2020. PMID: 31792071 Free PMC article.

5

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes.

Leung KK, Wilson GM, Kirkemo LL, Riley NM, Coon JJ, Wells JA. Leung KK, et al. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7764-7775. doi: 10.1073/pnas.1917947117. Epub 2020 Mar 23. Proc Natl Acad Sci U S A. 2020. PMID: 32205440 Free PMC article.

6

Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer.

Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ. Moroz A, et al. Among authors: leung kk. Clin Cancer Res. 2020 Jul 15;26(14):3608-3615. doi: 10.1158/1078-0432.CCR-20-0268. Epub 2020 Apr 27. Clin Cancer Res. 2020. PMID: 32341034 Free PMC article.

7

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.

Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. Glasgow A, et al. Among authors: leung kk. bioRxiv [Preprint]. 2020 Aug 4:2020.07.31.231746. doi: 10.1101/2020.07.31.231746. bioRxiv. 2020. PMID: 32766586 Free PMC article. Updated. Preprint.

8

Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps.

Zhou XX, Bracken CJ, Zhang K, Zhou J, Mou Y, Wang L, Cheng Y, Leung KK, Wells JA. Zhou XX, et al. Among authors: leung kk. J Am Chem Soc. 2020 Oct 14;142(41):17703-17713. doi: 10.1021/jacs.0c08458. Epub 2020 Sep 29. J Am Chem Soc. 2020. PMID: 32924468 Free PMC article.

9

Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding.

Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk RP, Chiu CY, Wang TT, Wilson MR, Leung KK, Wells JA. Byrnes JR, et al. Among authors: leung kk. mSphere. 2020 Sep 16;5(5):e00802-20. doi: 10.1128/mSphere.00802-20. mSphere. 2020. PMID: 32938700 Free PMC article.

10

Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries.

Zhou J, Li S, Leung KK, O'Donovan B, Zou JY, DeRisi JL, Wells JA. Zhou J, et al. Among authors: leung kk. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25464-25475. doi: 10.1073/pnas.2009279117. Epub 2020 Sep 24. Proc Natl Acad Sci U S A. 2020. PMID: 32973096 Free PMC article.

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