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Lipid nanoparticle technology for therapeutic gene regulation in the liver.
Witzigmann D, Kulkarni JA, Leung J, Chen S, Cullis PR, van der Meel R. Witzigmann D, et al. Among authors: leung j. Adv Drug Deliv Rev. 2020;159:344-363. doi: 10.1016/j.addr.2020.06.026. Epub 2020 Jul 2. Adv Drug Deliv Rev. 2020. PMID: 32622021 Free PMC article. Review.
Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
Strilchuk AW, Meixner SC, Leung J, Safikhan NS, Kulkarni JA, Russell HM, van der Meel R, Sutherland MR, Owens AP, Palumbo JS, Conway EM, Pryzdial ELG, Cullis PR, Kastrup CJ. Strilchuk AW, et al. Among authors: leung j. Blood. 2020 Dec 17;136(25):2946-2954. doi: 10.1182/blood.2020004976. Blood. 2020. PMID: 32678423 Free PMC article.
Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles.
Kulkarni JA , Thomson SB , Zaifman J , Leung J , Wagner PK , Hill A , Tam YYC , Cullis PR , Petkau TL , Leavitt BR . Kulkarni JA , et al. Among authors: leung j. Nanoscale. 2020 Dec 21;12(47):23959-23966. doi: 10.1039/d0nr06816k. Epub 2020 Nov 26. Nanoscale. 2020. PMID: 33241838
Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles.
Kamanzi A, Gu Y, Tahvildari R, Friedenberger Z, Zhu X, Berti R, Kurylowicz M, Witzigmann D, Kulkarni JA, Leung J, Andersson J, Dahlin A, Höök F, Sutton M, Cullis PR, Leslie S. Kamanzi A, et al. Among authors: leung j. ACS Nano. 2021 Dec 28;15(12):19244-19255. doi: 10.1021/acsnano.1c04862. Epub 2021 Nov 29. ACS Nano. 2021. PMID: 34843205
Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA.
Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, Flick MJ, Kastrup CJ. Juang LJ, et al. Among authors: leung j. Blood. 2022 Mar 3;139(9):1302-1311. doi: 10.1182/blood.2021014559. Blood. 2022. PMID: 34958662 Free PMC article.
Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin.
Bolsoni J, Liu D, Mohabatpour F, Ebner R, Sadhnani G, Tafech B, Leung J, Shanta S, An K, Morin T, Chen Y, Arguello A, Choate K, Jan E, Ross CJD, Brambilla D, Witzigmann D, Kulkarni J, Cullis PR, Hedtrich S. Bolsoni J, et al. Among authors: leung j. ACS Nano. 2023 Nov 14;17(21):22046-22059. doi: 10.1021/acsnano.3c08644. Epub 2023 Nov 2. ACS Nano. 2023. PMID: 37918441 Free PMC article.
Genetically engineered transfusable platelets using mRNA lipid nanoparticles.
Leung J, Strong C, Badior KE, Robertson M, Wu X, Meledeo MA, Kang E, Paul M, Sato Y, Harashima H, Cap AP, Devine DV, Jan E, Cullis PR, Kastrup CJ. Leung J, et al. Sci Adv. 2023 Dec;9(48):eadi0508. doi: 10.1126/sciadv.adi0508. Epub 2023 Dec 1. Sci Adv. 2023. PMID: 38039367 Free PMC article.
2,717 results