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Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.
Silva LM, Doyle AD, Greenwell-Wild T, Dutzan N, Tran CL, Abusleme L, Juang LJ, Leung J, Chun EM, Lum AG, Agler CS, Zuazo CE, Sibree M, Jani P, Kram V, Martin D, Moss K, Lionakis MS, Castellino FJ, Kastrup CJ, Flick MJ, Divaris K, Bugge TH, Moutsopoulos NM. Silva LM, et al. Among authors: leung j. Science. 2021 Dec 24;374(6575):eabl5450. doi: 10.1126/science.abl5450. Epub 2021 Dec 24. Science. 2021. PMID: 34941394
Sustained depletion of FXIII-A by inducing acquired FXIII-B deficiency.
Strilchuk AW, Meixner SC, Leung J, Safikhan NS, Kulkarni JA, Russell HM, van der Meel R, Sutherland MR, Owens AP, Palumbo JS, Conway EM, Pryzdial ELG, Cullis PR, Kastrup CJ. Strilchuk AW, et al. Among authors: leung j. Blood. 2020 Dec 17;136(25):2946-2954. doi: 10.1182/blood.2020004976. Blood. 2020. PMID: 32678423 Free PMC article.
Suppression of fibrin(ogen)-driven pathologies in disease models through controlled knockdown by lipid nanoparticle delivery of siRNA.
Juang LJ, Hur WS, Silva LM, Strilchuk AW, Francisco B, Leung J, Robertson MK, Groeneveld DJ, La Prairie B, Chun EM, Cap AP, Luyendyk JP, Palumbo JS, Cullis PR, Bugge TH, Flick MJ, Kastrup CJ. Juang LJ, et al. Among authors: leung j. Blood. 2022 Mar 3;139(9):1302-1311. doi: 10.1182/blood.2021014559. Blood. 2022. PMID: 34958662 Free PMC article.
Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state.
Hernandez GE, Ma F, Martinez G, Firozabadi NB, Salvador J, Juang LJ, Leung J, Zhao P, López DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe ML. Hernandez GE, et al. Among authors: leung j. Nat Cardiovasc Res. 2022 Jan;1(1):67-84. doi: 10.1038/s44161-021-00006-4. Epub 2022 Jan 12. Nat Cardiovasc Res. 2022. PMID: 35599984 Free PMC article.
Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet-induced obesity and associated pathologies.
Hur WS, King KC, Patel YN, Nguyen YV, Wei Z, Yang Y, Juang LJ, Leung J, Kastrup CJ, Wolberg AS, Luyendyk JP, Flick MJ. Hur WS, et al. Among authors: leung j. J Thromb Haemost. 2022 Dec;20(12):2873-2886. doi: 10.1111/jth.15877. Epub 2022 Oct 11. J Thromb Haemost. 2022. PMID: 36111375 Free PMC article.
Genetically engineered transfusable platelets using mRNA lipid nanoparticles.
Leung J, Strong C, Badior KE, Robertson M, Wu X, Meledeo MA, Kang E, Paul M, Sato Y, Harashima H, Cap AP, Devine DV, Jan E, Cullis PR, Kastrup CJ. Leung J, et al. Sci Adv. 2023 Dec;9(48):eadi0508. doi: 10.1126/sciadv.adi0508. Epub 2023 Dec 1. Sci Adv. 2023. PMID: 38039367 Free PMC article.
Lipid nanoparticles and siRNA targeting plasminogen provide lasting inhibition of fibrinolysis in mouse and dog models of hemophilia A.
Strilchuk AW, Hur WS, Batty P, Sang Y, Abrahams SR, Yong ASM, Leung J, Silva LM, Schroeder JA, Nesbitt K, de Laat B, Moutsopoulos NM, Bugge TH, Shi Q, Cullis PR, Merricks EP, Wolberg AS, Flick MJ, Lillicrap D, Nichols TC, Kastrup CJ. Strilchuk AW, et al. Among authors: leung j. Sci Transl Med. 2024 Feb 21;16(735):eadh0027. doi: 10.1126/scitranslmed.adh0027. Epub 2024 Feb 21. Sci Transl Med. 2024. PMID: 38381848
2,724 results