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Novel Inhibitors of DNA Repair Enzyme TDP1 Combining Monoterpenoid and Adamantane Fragments.
Mozhaitsev ES, Zakharenko AL, Suslov EV, Korchagina DV, Zakharova OD, Vasil'eva IA, Chepanova AA, Black E, Patel J, Chand R, Reynisson J, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI. Mozhaitsev ES, et al. Among authors: leung ikh. Anticancer Agents Med Chem. 2019;19(4):463-472. doi: 10.2174/1871520619666181207094243. Anticancer Agents Med Chem. 2019. PMID: 30523770
Virtual screening and biophysical studies lead to HSP90 inhibitors.
Huang R, Ayine-Tora DM, Muhammad Rosdi MN, Li Y, Reynisson J, Leung IKH. Huang R, et al. Among authors: leung ikh. Bioorg Med Chem Lett. 2017 Jan 15;27(2):277-281. doi: 10.1016/j.bmcl.2016.11.059. Epub 2016 Nov 23. Bioorg Med Chem Lett. 2017. PMID: 27913182
Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
Zakharenko AL, Luzina OA, Sokolov DN, Kaledin VI, Nikolin VP, Popova NA, Patel J, Zakharova OD, Chepanova AA, Zafar A, Reynisson J, Leung E, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI. Zakharenko AL, et al. Among authors: leung e, leung ikh. Eur J Med Chem. 2019 Jan 1;161:581-593. doi: 10.1016/j.ejmech.2018.10.055. Epub 2018 Oct 28. Eur J Med Chem. 2019. PMID: 30396105
New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.
Filimonov AS, Chepanova AA, Luzina OA, Zakharenko AL, Zakharova OD, Ilina ES, Dyrkheeva NS, Kuprushkin MS, Kolotaev AV, Khachatryan DS, Patel J, Leung IKH, Chand R, Ayine-Tora DM, Reynisson J, Volcho KP, Salakhutdinov NF, Lavrik OI. Filimonov AS, et al. Among authors: leung ikh. Molecules. 2019 Oct 15;24(20):3711. doi: 10.3390/molecules24203711. Molecules. 2019. PMID: 31619021 Free PMC article.
Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.
Khomenko TM, Zakharenko AL, Chepanova AA, Ilina ES, Zakharova OD, Kaledin VI, Nikolin VP, Popova NA, Korchagina DV, Reynisson J, Chand R, Ayine-Tora DM, Patel J, Leung IKH, Volcho KP, Salakhutdinov NF, Lavrik OI. Khomenko TM, et al. Among authors: leung ikh. Int J Mol Sci. 2019 Dec 23;21(1):126. doi: 10.3390/ijms21010126. Int J Mol Sci. 2019. PMID: 31878088 Free PMC article.
69 results