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Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression.
Wall MJ, Hill E, Huckstepp R, Barkan K, Deganutti G, Leuenberger M, Preti B, Winfield I, Carvalho S, Suchankova A, Wei H, Safitri D, Huang X, Imlach W, La Mache C, Dean E, Hume C, Hayward S, Oliver J, Zhao FY, Spanswick D, Reynolds CA, Lochner M, Ladds G, Frenguelli BG. Wall MJ, et al. Among authors: leuenberger m. Nat Commun. 2022 Jul 18;13(1):4150. doi: 10.1038/s41467-022-31652-2. Nat Commun. 2022. PMID: 35851064 Free PMC article.
Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.
Knight A, Hemmings JL, Winfield I, Leuenberger M, Frattini E, Frenguelli BG, Dowell SJ, Lochner M, Ladds G. Knight A, et al. Among authors: leuenberger m. J Med Chem. 2016 Feb 11;59(3):947-64. doi: 10.1021/acs.jmedchem.5b01402. Epub 2016 Feb 1. J Med Chem. 2016. PMID: 26756468 Free article.
Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor.
Deganutti G, Barkan K, Preti B, Leuenberger M, Wall M, Frenguelli BG, Lochner M, Ladds G, Reynolds CA. Deganutti G, et al. Among authors: leuenberger m. ACS Pharmacol Transl Sci. 2021 Jan 21;4(1):314-326. doi: 10.1021/acsptsci.0c00195. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2021. PMID: 33615181 Free PMC article.
119 results