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Intra-Domain Cysteines (IDC), a New Strategy for the Development of Original Antibody Fragment-Drug Conjugates (FDCs).
Pharmaceutics. 2022 Jul 22;14(8):1524. doi: 10.3390/pharmaceutics14081524.
Pharmaceutics. 2022.
PMID: 35893780
Free PMC article.
Impact of cathepsin B-sensitive triggers and hydrophilic linkers on in vitro efficacy of novel site-specific antibody-drug conjugates.
Bryden F, Martin C, Letast S, Lles E, Viéitez-Villemin I, Rousseau A, Colas C, Brachet-Botineau M, Allard-Vannier E, Larbouret C, Viaud-Massuard MC, Joubert N.
Bryden F, et al. Among authors: letast s.
Org Biomol Chem. 2018 Mar 14;16(11):1882-1889. doi: 10.1039/c7ob02780j.
Org Biomol Chem. 2018.
PMID: 29473076
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Site-Specific Conjugation of Auristatins onto Engineered scFv Using Second Generation Maleimide to Target HER2-positive Breast Cancer in Vitro.
Aubrey N, Allard-Vannier E, Martin C, Bryden F, Letast S, Colas C, Lakhrif Z, Collinet N, Dimier-Poisson I, Chourpa I, Viaud-Massuard MC, Joubert N.
Aubrey N, et al. Among authors: letast s.
Bioconjug Chem. 2018 Nov 21;29(11):3516-3521. doi: 10.1021/acs.bioconjchem.8b00668. Epub 2018 Oct 25.
Bioconjug Chem. 2018.
PMID: 30352511
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Dual intra- and extracellular release of monomethyl auristatin E from a neutrophil elastase-sensitive antibody-drug conjugate.
Mohamed Amar IA, Huvelle S, Douez E, Letast S, Henrion S, Viaud-Massuard MC, Aubrey N, Allard-Vannier E, Joubert N, Denevault-Sabourin C.
Mohamed Amar IA, et al. Among authors: letast s.
Eur J Med Chem. 2022 Feb 5;229:114063. doi: 10.1016/j.ejmech.2021.114063. Epub 2021 Dec 24.
Eur J Med Chem. 2022.
PMID: 34974337
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Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells.
Corvaglia V, Ait Mohamed Amar I, Garambois V, Letast S, Garcin A, Gongora C, Del Rio M, Denevault-Sabourin C, Joubert N, Huc I, Pourquier P.
Corvaglia V, et al. Among authors: letast s.
Pharmaceuticals (Basel). 2021 Jun 28;14(7):624. doi: 10.3390/ph14070624.
Pharmaceuticals (Basel). 2021.
PMID: 34203395
Free PMC article.
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Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).
Korkmaz B, Lesner A, Letast S, Mahdi YK, Jourdan ML, Dallet-Choisy S, Marchand-Adam S, Kellenberger C, Viaud-Massuard MC, Jenne DE, Gauthier F.
Korkmaz B, et al. Among authors: letast s.
Semin Immunopathol. 2013 Jul;35(4):411-21. doi: 10.1007/s00281-013-0362-z. Epub 2013 Feb 6.
Semin Immunopathol. 2013.
PMID: 23385856
Review.
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Branched pegylated linker-auristatin to control hydrophobicity for the production of homogeneous minibody-drug conjugate against HER2-positive breast cancer.
Douez E, Allard-Vannier E, Amar IAM, Jolivet L, Boursin F, Maisonial-Besset A, Witkowski T, Chezal JM, Colas C, Letast S, Auvert E, Denevault-Sabourin C, Aubrey N, Joubert N.
Douez E, et al. Among authors: letast s.
J Control Release. 2024 Feb;366:567-584. doi: 10.1016/j.jconrel.2024.01.012. Epub 2024 Jan 13.
J Control Release. 2024.
PMID: 38215985
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