Letai A - Search Results

1

ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins.

Alcon C, Gómez Tejeda Zañudo J, Albert R, Wagle N, Scaltriti M, Letai A, Samitier J, Montero J. Alcon C, et al. Among authors: letai a. Cells. 2021 Jul 2;10(7):1659. doi: 10.3390/cells10071659. Cells. 2021. PMID: 34359829 Free PMC article.

2

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. Blood. 2008 Feb 15;111(4):2300-9. doi: 10.1182/blood-2007-06-098012. Epub 2007 Dec 4. Blood. 2008. PMID: 18056841 Free PMC article.

3

Rational design of therapeutics targeting the BCL-2 family: are some cancer cells primed for death but waiting for a final push?

Del Gaizo Moore V, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. Adv Exp Med Biol. 2008;615:159-75. doi: 10.1007/978-1-4020-6554-5_8. Adv Exp Med Biol. 2008. PMID: 18437895 Review.

4

Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737.

Kutuk O, Letai A. Kutuk O, et al. Among authors: letai a. Cancer Res. 2008 Oct 1;68(19):7985-94. doi: 10.1158/0008-5472.CAN-08-1418. Cancer Res. 2008. PMID: 18829556 Free PMC article.

5

MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts.

Brunelle JK, Ryan J, Yecies D, Opferman JT, Letai A. Brunelle JK, et al. Among authors: letai a. J Cell Biol. 2009 Nov 2;187(3):429-42. doi: 10.1083/jcb.200904049. Epub 2009 Oct 26. J Cell Biol. 2009. PMID: 19948485 Free PMC article.

6

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

Yecies D, Carlson NE, Deng J, Letai A. Yecies D, et al. Among authors: letai a. Blood. 2010 Apr 22;115(16):3304-13. doi: 10.1182/blood-2009-07-233304. Epub 2010 Mar 2. Blood. 2010. PMID: 20197552 Free PMC article.

7

BH3-only proteins and their effects on cancer.

Vo TT, Letai A. Vo TT, et al. Among authors: letai a. Adv Exp Med Biol. 2010;687:49-63. doi: 10.1007/978-1-4419-6706-0_3. Adv Exp Med Biol. 2010. PMID: 20919637 Free PMC article. Review.

8

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

Ercan D, Xu C, Yanagita M, Monast CS, Pratilas CA, Montero J, Butaney M, Shimamura T, Sholl L, Ivanova EV, Tadi M, Rogers A, Repellin C, Capelletti M, Maertens O, Goetz EM, Letai A, Garraway LA, Lazzara MJ, Rosen N, Gray NS, Wong KK, Jänne PA. Ercan D, et al. Among authors: letai a. Cancer Discov. 2012 Oct;2(10):934-47. doi: 10.1158/2159-8290.CD-12-0103. Epub 2012 Sep 7. Cancer Discov. 2012. PMID: 22961667 Free PMC article.

9

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.

Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, Christie AL, McCauley D, Rodig SJ, Kauffman M, Shacham S, Stone R, Letai A, Kung AL, Thomas Look A. Etchin J, et al. Among authors: letai a. Br J Haematol. 2013 Apr;161(1):117-27. doi: 10.1111/bjh.12231. Epub 2013 Feb 4. Br J Haematol. 2013. PMID: 23373539 Free PMC article.

10

BCL-2 inhibition: stemming the tide of myeloid malignancies.

Hogdal LJ, Letai A. Hogdal LJ, et al. Among authors: letai a. Cell Stem Cell. 2013 Mar 7;12(3):269-70. doi: 10.1016/j.stem.2013.02.006. Cell Stem Cell. 2013. PMID: 23472867 Free PMC article.

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