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Exploring ITM2A as a new potential target for brain delivery.
Cegarra C, Chaves C, Déon C, Do TM, Dumas B, Frenzel A, Kuhn P, Roudieres V, Guillemot JC, Lesuisse D. Cegarra C, et al. Among authors: lesuisse d. Fluids Barriers CNS. 2022 Mar 21;19(1):25. doi: 10.1186/s12987-022-00321-3. Fluids Barriers CNS. 2022. PMID: 35313913 Free PMC article.
Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model.
Do TM, Capdevila C, Pradier L, Blanchard V, Lopez-Grancha M, Schussler N, Steinmetz A, Beninga J, Boulay D, Dugay P, Verdier P, Aubin N, Dargazanli G, Chaves C, Genet E, Lossouarn Y, Loux C, Michoux F, Moindrot N, Chanut F, Gury T, Eyquem S, Valente D, Bergis O, Rao E, Lesuisse D. Do TM, et al. Among authors: lesuisse d. Mol Ther Methods Clin Dev. 2020 Aug 21;19:58-77. doi: 10.1016/j.omtm.2020.08.014. eCollection 2020 Dec 11. Mol Ther Methods Clin Dev. 2020. PMID: 33005703 Free PMC article.
Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease.
Lesuisse D, Malanda A, Peyronel JF, Evanno Y, Lardenois P, De-Peretti D, Abécassis PY, Barnéoud P, Brunel P, Burgevin MC, Cegarra C, Auger F, Dommergue A, Lafon C, Even L, Tsi J, Luc TPH, Almario A, Olivier A, Castel MN, Taupin V, Rooney T, Vigé X. Lesuisse D, et al. Bioorg Med Chem Lett. 2019 Apr 1;29(7):929-932. doi: 10.1016/j.bmcl.2019.01.024. Epub 2019 Jan 30. Bioorg Med Chem Lett. 2019. PMID: 30773432
Peptidomics of Haemonchus contortus.
Buzy A, Allain C, Harrington J, Lesuisse D, Mikol V, Bruhn DF, Maule AG, Guillemot JC. Buzy A, et al. Among authors: lesuisse d. ACS Omega. 2021 Apr 7;6(15):10288-10305. doi: 10.1021/acsomega.1c00650. eCollection 2021 Apr 20. ACS Omega. 2021. PMID: 34056183 Free PMC article.
Data on synthesis, ADME and pharmacological properties and early safety pharmacology evaluation of a series of novel NURR1/NOT agonist potentially useful for the treatment of Parkinson's disease.
Malanda A, Abécassis PY, Barnéoud P, Brunel P, Taupin V, Vigé X, Lesuisse D. Malanda A, et al. Among authors: lesuisse d. Data Brief. 2019 May 27;27:104057. doi: 10.1016/j.dib.2019.104057. eCollection 2019 Dec. Data Brief. 2019. PMID: 31687426 Free PMC article.
Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Lesuisse D, Dutruc-Rosset G, Tiraboschi G, Dreyer MK, Maignan S, Chevalier A, Halley F, Bertrand P, Burgevin MC, Quarteronet D, Rooney T. Lesuisse D, et al. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. doi: 10.1016/j.bmcl.2010.01.114. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20167481
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