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Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes.
Zubiaga L, Briand O, Auger F, Touche V, Hubert T, Thevenet J, Marciniak C, Quenon A, Bonner C, Peschard S, Raverdy V, Daoudi M, Kerr-Conte J, Pasquetti G, Koepsell H, Zdzieblo D, Mühlemann M, Thorens B, Delzenne ND, Bindels LB, Deprez B, Vantyghem MC, Laferrère B, Staels B, Huglo D, Lestavel S, Pattou F. Zubiaga L, et al. Among authors: lestavel s. iScience. 2023 Jan 25;26(4):106057. doi: 10.1016/j.isci.2023.106057. eCollection 2023 Apr 21. iScience. 2023. PMID: 36942050 Free PMC article.
The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia.
Lalloyer F, Fiévet C, Lestavel S, Torpier G, van der Veen J, Touche V, Bultel S, Yous S, Kuipers F, Paumelle R, Fruchart JC, Staels B, Tailleux A. Lalloyer F, et al. Among authors: lestavel s. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2731-7. doi: 10.1161/01.ATV.0000248101.93488.84. Epub 2006 Sep 28. Arterioscler Thromb Vasc Biol. 2006. PMID: 17008586
PPARβ/δ activation induces enteroendocrine L cell GLP-1 production.
Daoudi M, Hennuyer N, Borland MG, Touche V, Duhem C, Gross B, Caiazzo R, Kerr-Conte J, Pattou F, Peters JM, Staels B, Lestavel S. Daoudi M, et al. Among authors: lestavel s. Gastroenterology. 2011 May;140(5):1564-74. doi: 10.1053/j.gastro.2011.01.045. Epub 2011 Feb 4. Gastroenterology. 2011. PMID: 21300064 Free article.
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity.
Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, Dumont J, Bouchaert E, van Dijk TH, Lucas A, Dorchies E, Daoudi M, Lestavel S, Gonzalez FJ, Oresic M, Cariou B, Kuipers F, Caron S, Staels B. Prawitt J, et al. Among authors: lestavel s. Diabetes. 2011 Jul;60(7):1861-71. doi: 10.2337/db11-0030. Epub 2011 May 18. Diabetes. 2011. PMID: 21593203 Free PMC article.
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.
Trabelsi MS, Daoudi M, Prawitt J, Ducastel S, Touche V, Sayin SI, Perino A, Brighton CA, Sebti Y, Kluza J, Briand O, Dehondt H, Vallez E, Dorchies E, Baud G, Spinelli V, Hennuyer N, Caron S, Bantubungi K, Caiazzo R, Reimann F, Marchetti P, Lefebvre P, Bäckhed F, Gribble FM, Schoonjans K, Pattou F, Tailleux A, Staels B, Lestavel S. Trabelsi MS, et al. Among authors: lestavel s. Nat Commun. 2015 Jul 2;6:7629. doi: 10.1038/ncomms8629. Nat Commun. 2015. PMID: 26134028 Free PMC article.
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