Lessnick SL - Search Results

1

Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response.

Pishas KI, Drenberg CD, Taslim C, Theisen ER, Johnson KM, Saund RS, Pop IL, Crompton BD, Lawlor ER, Tirode F, Mora J, Delattre O, Beckerle MC, Callen DF, Sharma S, Lessnick SL. Pishas KI, et al. Among authors: lessnick sl. Mol Cancer Ther. 2018 Sep;17(9):1902-1916. doi: 10.1158/1535-7163.MCT-18-0373. Epub 2018 Jul 11. Mol Cancer Ther. 2018. PMID: 29997151 Free PMC article.

2

Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.

Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, Beckerle MC, Sharma S, Lessnick SL. Sankar S, et al. Among authors: lessnick sl. Clin Cancer Res. 2014 Sep 1;20(17):4584-97. doi: 10.1158/1078-0432.CCR-14-0072. Epub 2014 Jun 24. Clin Cancer Res. 2014. PMID: 24963049 Free PMC article.

3

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting.

Theisen ER, Pishas KI, Saund RS, Lessnick SL. Theisen ER, et al. Among authors: lessnick sl. Oncotarget. 2016 Apr 5;7(14):17616-30. doi: 10.18632/oncotarget.7124. Oncotarget. 2016. PMID: 26848860 Free PMC article. Review.

4

Recent advances in targeted therapy for Ewing sarcoma.

Pishas KI, Lessnick SL. Pishas KI, et al. Among authors: lessnick sl. F1000Res. 2016 Aug 25;5:F1000 Faculty Rev-2077. doi: 10.12688/f1000research.8631.1. eCollection 2016. F1000Res. 2016. PMID: 27635231 Free PMC article. Review.

5

Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma.

Johnson KM, Taslim C, Saund RS, Lessnick SL. Johnson KM, et al. Among authors: lessnick sl. PLoS One. 2017 Nov 1;12(11):e0186275. doi: 10.1371/journal.pone.0186275. eCollection 2017. PLoS One. 2017. PMID: 29091716 Free PMC article.

6

Ewing sarcoma resistance to SP-2509 is not mediated through KDM1A/LSD1 mutation.

Pishas KI, Lessnick SL. Pishas KI, et al. Among authors: lessnick sl. Oncotarget. 2018 Nov 23;9(92):36413-36429. doi: 10.18632/oncotarget.26326. eCollection 2018 Nov 23. Oncotarget. 2018. PMID: 30559927 Free PMC article.

7

The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma.

Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC. Chaturvedi A, et al. Among authors: lessnick sl. Genes Cancer. 2012 Feb;3(2):102-16. doi: 10.1177/1947601912457024. Genes Cancer. 2012. PMID: 23050043 Free PMC article.

8

A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma.

Sankar S, Tanner JM, Bell R, Chaturvedi A, Randall RL, Beckerle MC, Lessnick SL. Sankar S, et al. Among authors: lessnick sl. Mol Cell Biol. 2013 Nov;33(22):4448-60. doi: 10.1128/MCB.00241-13. Epub 2013 Sep 16. Mol Cell Biol. 2013. PMID: 24043308 Free PMC article.

9

ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma.

Wiles ET, Bell R, Thomas D, Beckerle M, Lessnick SL. Wiles ET, et al. Among authors: lessnick sl. Genes Cancer. 2013 Nov;4(11-12):486-500. doi: 10.1177/1947601913506115. Genes Cancer. 2013. PMID: 24386509 Free PMC article.

10

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.

Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC. Chaturvedi A, et al. Among authors: lessnick sl. Mol Biol Cell. 2014 Sep 15;25(18):2695-709. doi: 10.1091/mbc.E14-01-0007. Epub 2014 Jul 23. Mol Biol Cell. 2014. PMID: 25057021 Free PMC article.

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