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Exploiting the S4-S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis.
Guarino C, Gruba N, Grzywa R, Dyguda-Kazimierowicz E, Hamon Y, Łȩgowska M, Skoreński M, Dallet-Choisy S, Marchand-Adam S, Kellenberger C, Jenne DE, Sieńczyk M, Lesner A, Gauthier F, Korkmaz B. Guarino C, et al. Among authors: lesner a. J Med Chem. 2018 Mar 8;61(5):1858-1870. doi: 10.1021/acs.jmedchem.7b01416. Epub 2018 Feb 26. J Med Chem. 2018. PMID: 29442501
New potent cathepsin G phosphonate inhibitors.
Sieńczyk M, Lesner A, Wysocka M, Legowska A, Pietrusewicz E, Rolka K, Oleksyszyn J. Sieńczyk M, et al. Among authors: lesner a. Bioorg Med Chem. 2008 Oct 1;16(19):8863-7. doi: 10.1016/j.bmc.2008.08.069. Epub 2008 Aug 31. Bioorg Med Chem. 2008. PMID: 18805698
Three wavelength substrate system of neutrophil serine proteinases.
Wysocka M, Lesner A, Gruba N, Korkmaz B, Gauthier F, Kitamatsu M, Łęgowska A, Rolka K. Wysocka M, et al. Among authors: lesner a. Anal Chem. 2012 Aug 21;84(16):7241-8. doi: 10.1021/ac301684w. Epub 2012 Aug 8. Anal Chem. 2012. PMID: 22823539
Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).
Korkmaz B, Lesner A, Letast S, Mahdi YK, Jourdan ML, Dallet-Choisy S, Marchand-Adam S, Kellenberger C, Viaud-Massuard MC, Jenne DE, Gauthier F. Korkmaz B, et al. Among authors: lesner a. Semin Immunopathol. 2013 Jul;35(4):411-21. doi: 10.1007/s00281-013-0362-z. Epub 2013 Feb 6. Semin Immunopathol. 2013. PMID: 23385856 Review.
Substrate specificity of human matriptase-2.
Wysocka M, Gruba N, Miecznikowska A, Popow-Stellmaszyk J, Gütschow M, Stirnberg M, Furtmann N, Bajorath J, Lesner A, Rolka K. Wysocka M, et al. Among authors: lesner a. Biochimie. 2014 Feb;97:121-7. doi: 10.1016/j.biochi.2013.10.001. Epub 2013 Oct 22. Biochimie. 2014. PMID: 24161741
125 results