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An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes.
Ben Maamar M, Lesné L, Desdoits-Lethimonier C, Coiffec I, Lassurguère J, Lavoué V, Deceuninck Y, Antignac JP, Le Bizec B, Perdu E, Zalko D, Pineau C, Chevrier C, Dejucq-Rainsford N, Mazaud-Guittot S, Jégou B. Ben Maamar M, et al. Among authors: lesne l. PLoS One. 2015 Feb 23;10(2):e0117226. doi: 10.1371/journal.pone.0117226. eCollection 2015. PLoS One. 2015. PMID: 25706302 Free PMC article.
Ibuprofen results in alterations of human fetal testis development.
Ben Maamar M, Lesné L, Hennig K, Desdoits-Lethimonier C, Kilcoyne KR, Coiffec I, Rolland AD, Chevrier C, Kristensen DM, Lavoué V, Antignac JP, Le Bizec B, Dejucq-Rainsford N, Mitchell RT, Mazaud-Guittot S, Jégou B. Ben Maamar M, et al. Among authors: lesne l. Sci Rep. 2017 Mar 10;7:44184. doi: 10.1038/srep44184. Sci Rep. 2017. PMID: 28281692 Free PMC article.
Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants.
Gaudriault P, Mazaud-Guittot S, Lavoué V, Coiffec I, Lesné L, Dejucq-Rainsford N, Scholze M, Kortenkamp A, Jégou B. Gaudriault P, et al. Among authors: lesne l. Environ Health Perspect. 2017 Aug 4;125(8):087004. doi: 10.1289/EHP1014. Environ Health Perspect. 2017. PMID: 28796631 Free PMC article.
Acetaminophen (APAP, Paracetamol) Interferes With the First Trimester Human Fetal Ovary Development in an Ex Vivo Model.
Lecante LL, Leverrier-Penna S, Gicquel T, Giton F, Costet N, Desdoits-Lethimonier C, Lesné L, Fromenty B, Lavoué V, Rolland AD, Mazaud-Guittot S. Lecante LL, et al. Among authors: lesne l. J Clin Endocrinol Metab. 2022 May 17;107(6):1647-1661. doi: 10.1210/clinem/dgac080. J Clin Endocrinol Metab. 2022. PMID: 35147701 Free PMC article.
Human testis steroidogenesis is inhibited by phthalates.
Desdoits-Lethimonier C, Albert O, Le Bizec B, Perdu E, Zalko D, Courant F, Lesné L, Guillé F, Dejucq-Rainsford N, Jégou B. Desdoits-Lethimonier C, et al. Among authors: lesne l. Hum Reprod. 2012 May;27(5):1451-9. doi: 10.1093/humrep/des069. Epub 2012 Mar 8. Hum Reprod. 2012. PMID: 22402212
Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.
Kristensen DM, Desdoits-Lethimonier C, Mackey AL, Dalgaard MD, De Masi F, Munkbøl CH, Styrishave B, Antignac JP, Le Bizec B, Platel C, Hay-Schmidt A, Jensen TK, Lesné L, Mazaud-Guittot S, Kristiansen K, Brunak S, Kjaer M, Juul A, Jégou B. Kristensen DM, et al. Among authors: lesne l. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E715-E724. doi: 10.1073/pnas.1715035115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311296 Free PMC article. Clinical Trial.
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