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Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms).
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ. de Gaetano M, et al. Among authors: leroy x. Eur J Med Chem. 2019 Jan 15;162:80-108. doi: 10.1016/j.ejmech.2018.10.049. Epub 2018 Oct 23. Eur J Med Chem. 2019. PMID: 30419493
Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms).
de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C, Guiry PJ. de Gaetano M, et al. Among authors: leroy x. J Med Chem. 2021 Jul 8;64(13):9193-9216. doi: 10.1021/acs.jmedchem.1c00403. Epub 2021 Jun 17. J Med Chem. 2021. PMID: 34138563 Free PMC article.
FPR2/ALXR agonists and the resolution of inflammation.
Corminboeuf O, Leroy X. Corminboeuf O, et al. Among authors: leroy x. J Med Chem. 2015 Jan 22;58(2):537-59. doi: 10.1021/jm501051x. Epub 2014 Nov 3. J Med Chem. 2015. PMID: 25365541
Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist.
Fretz H, Valdenaire A, Pothier J, Hilpert K, Gnerre C, Peter O, Leroy X, Riederer MA. Fretz H, et al. Among authors: leroy x. J Med Chem. 2013 Jun 27;56(12):4899-911. doi: 10.1021/jm400122f. Epub 2013 Jun 13. J Med Chem. 2013. PMID: 23721423
[No title available]
[No authors listed] [No authors listed] PMID: 35555261
258 results