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Page 1
Analytical validation of a next generation sequencing liquid biopsy assay for high sensitivity broad molecular profiling.
Plagnol V, Woodhouse S, Howarth K, Lensing S, Smith M, Epstein M, Madi M, Smalley S, Leroy C, Hinton J, de Kievit F, Musgrave-Brown E, Herd C, Baker-Neblett K, Brennan W, Dimitrov P, Campbell N, Morris C, Rosenfeld N, Clark J, Gale D, Platt J, Calaway J, Jones G, Forshew T. Plagnol V, et al. Among authors: leroy c. PLoS One. 2018 Mar 15;13(3):e0193802. doi: 10.1371/journal.pone.0193802. eCollection 2018. PLoS One. 2018. PMID: 29543828 Free PMC article.
RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.
Papaemmanuil E, Rapado I, Li Y, Potter NE, Wedge DC, Tubio J, Alexandrov LB, Van Loo P, Cooke SL, Marshall J, Martincorena I, Hinton J, Gundem G, van Delft FW, Nik-Zainal S, Jones DR, Ramakrishna M, Titley I, Stebbings L, Leroy C, Menzies A, Gamble J, Robinson B, Mudie L, Raine K, O'Meara S, Teague JW, Butler AP, Cazzaniga G, Biondi A, Zuna J, Kempski H, Muschen M, Ford AM, Stratton MR, Greaves M, Campbell PJ. Papaemmanuil E, et al. Among authors: leroy c. Nat Genet. 2014 Feb;46(2):116-25. doi: 10.1038/ng.2874. Epub 2014 Jan 12. Nat Genet. 2014. PMID: 24413735 Free PMC article.
Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.
Montagne R, Berbon M, Doublet L, Debreuck N, Baranzelli A, Drobecq H, Leroy C, Delhem N, Porte H, Copin MC, Dansin E, Furlan A, Tulasne D. Montagne R, et al. Among authors: leroy c. Cell Death Dis. 2015 May 21;6(5):e1769. doi: 10.1038/cddis.2015.132. Cell Death Dis. 2015. PMID: 25996296 Free PMC article.
Caspase cleavage of the MET receptor generates an HGF interfering fragment.
Deheuninck J, Foveau B, Goormachtigh G, Leroy C, Ji Z, Tulasne D, Fafeur V. Deheuninck J, et al. Among authors: leroy c. Biochem Biophys Res Commun. 2008 Mar 14;367(3):573-7. doi: 10.1016/j.bbrc.2007.12.177. Epub 2008 Jan 8. Biochem Biophys Res Commun. 2008. PMID: 18187039
Met degradation: more than one stone to shoot a receptor down.
Lefebvre J, Ancot F, Leroy C, Muharram G, Lemière A, Tulasne D. Lefebvre J, et al. Among authors: leroy c. FASEB J. 2012 Apr;26(4):1387-99. doi: 10.1096/fj.11-197723. Epub 2012 Jan 5. FASEB J. 2012. PMID: 22223753 Review.
830 results