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Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer.
Joanito I, Wirapati P, Zhao N, Nawaz Z, Yeo G, Lee F, Eng CLP, Macalinao DC, Kahraman M, Srinivasan H, Lakshmanan V, Verbandt S, Tsantoulis P, Gunn N, Venkatesh PN, Poh ZW, Nahar R, Oh HLJ, Loo JM, Chia S, Cheow LF, Cheruba E, Wong MT, Kua L, Chua C, Nguyen A, Golovan J, Gan A, Lim WJ, Guo YA, Yap CK, Tay B, Hong Y, Chong DQ, Chok AY, Park WY, Han S, Chang MH, Seow-En I, Fu C, Mathew R, Toh EL, Hong LZ, Skanderup AJ, DasGupta R, Ong CJ, Lim KH, Tan EKW, Koo SL, Leow WQ, Tejpar S, Prabhakar S, Tan IB. Joanito I, et al. Among authors: leow wq. Nat Genet. 2022 Jul;54(7):963-975. doi: 10.1038/s41588-022-01100-4. Epub 2022 Jun 30. Nat Genet. 2022. PMID: 35773407 Free PMC article.
Impact of fatty liver on long-term outcomes in chronic hepatitis B: a systematic review and matched analysis of individual patient data meta-analysis.
Wong YJ, Nguyen VH, Yang HI, Li J, Le MH, Wu WJ, Han NX, Fong KY, Chen E, Wong C, Rui F, Xu X, Xue Q, Hu XY, Leow WQ, Goh GB, Cheung R, Wong G, Wong VW, Yu MW, Nguyen MH. Wong YJ, et al. Among authors: leow wq. Clin Mol Hepatol. 2023 Jul;29(3):705-720. doi: 10.3350/cmh.2023.0004. Epub 2023 May 8. Clin Mol Hepatol. 2023. PMID: 37157776 Free PMC article.
Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer.
Suzuki Y, Ng SB, Chua C, Leow WQ, Chng J, Liu SY, Ramnarayanan K, Gan A, Ho DL, Ten R, Su Y, Lezhava A, Lai JH, Koh D, Lim KH, Tan P, Rozen SG, Tan IB. Suzuki Y, et al. Among authors: leow wq. Mol Oncol. 2017 Feb;11(2):124-139. doi: 10.1002/1878-0261.12012. Epub 2016 Oct 20. Mol Oncol. 2017. PMID: 28145097 Free PMC article. Clinical Trial.
CD30+OX40+ Treg is associated with improved overall survival in colorectal cancer.
Lam JH, Hong M, Koo SL, Chua CWL, Lim KL, Wee F, Wan WK, Leow WQ, Yeo JG, Tan IBH, Yeong J, Lim TKH, Lim TS. Lam JH, et al. Among authors: leow wq. Cancer Immunol Immunother. 2021 Aug;70(8):2353-2365. doi: 10.1007/s00262-021-02859-x. Epub 2021 Feb 2. Cancer Immunol Immunother. 2021. PMID: 33527196 Free PMC article.
Trajectory of immune evasion and cancer progression in hepatocellular carcinoma.
Nguyen PHD, Wasser M, Tan CT, Lim CJ, Lai HLH, Seow JJW, DasGupta R, Phua CZJ, Ma S, Yang J, Suthen SD, Tam WL, Lim TKH, Yeong J, Leow WQ, Pang YH, Soon G, Loh TJ, Wan WK, Chan CY, Cheow PC, Toh HC, Kow A, Dan YY, Kam JH, Iyer S, Madhavan K, Chung A, Bonney GK, Goh BKP, Fu N, Yu VC, Zhai W, Albani S, Chow PKH, Chew V. Nguyen PHD, et al. Among authors: leow wq. Nat Commun. 2022 Mar 17;13(1):1441. doi: 10.1038/s41467-022-29122-w. Nat Commun. 2022. PMID: 35301339 Free PMC article.
Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma.
Nguyen PHD, Ma S, Phua CZJ, Kaya NA, Lai HLH, Lim CJ, Lim JQ, Wasser M, Lai L, Tam WL, Lim TKH, Wan WK, Loh T, Leow WQ, Pang YH, Chan CY, Lee SY, Cheow PC, Toh HC, Ginhoux F, Iyer S, Kow AWC, Young Dan Y, Chung A, Bonney GK, Goh BKP, Albani S, Chow PKH, Zhai W, Chew V. Nguyen PHD, et al. Among authors: leow wq. Nat Commun. 2021 Jan 11;12(1):227. doi: 10.1038/s41467-020-20171-7. Nat Commun. 2021. PMID: 33431814 Free PMC article.
Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study.
Zhai W, Lai H, Kaya NA, Chen J, Yang H, Lu B, Lim JQ, Ma S, Chew SC, Chua KP, Alvarez JJS, Chen PJ, Chang MM, Wu L, Goh BKP, Chung AY, Chan CY, Cheow PC, Lee SY, Kam JH, Kow AW, Ganpathi IS, Chanwat R, Thammasiri J, Yoong BK, Ong DB, de Villa VH, Dela Cruz RD, Loh TJ, Wan WK, Zeng Z, Skanderup AJ, Pang YH, Madhavan K, Lim TK, Bonney G, Leow WQ, Chew V, Dan YY, Tam WL, Toh HC, Foo RS, Chow PK. Zhai W, et al. Among authors: leow wq. Natl Sci Rev. 2021 Oct 29;9(3):nwab192. doi: 10.1093/nsr/nwab192. eCollection 2022 Mar. Natl Sci Rev. 2021. PMID: 35382356 Free PMC article.
57 results