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Evolution-guided engineering of trans-acyltransferase polyketide synthases.
Science. 2024 Mar 22;383(6689):1312-1317. doi: 10.1126/science.adj7621. Epub 2024 Mar 21.
Science. 2024.
PMID: 38513027
Artificial intelligence for natural product drug discovery.
Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH.
Mullowney MW, et al. Among authors: leopold messer s.
Nat Rev Drug Discov. 2023 Nov;22(11):895-916. doi: 10.1038/s41573-023-00774-7. Epub 2023 Sep 11.
Nat Rev Drug Discov. 2023.
PMID: 37697042
Review.
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Integration host factor regulates colonization factors in the bee gut symbiont Frischella perrara.
Schmidt K, Santos-Matos G, Leopold-Messer S, El Chazli Y, Emery O, Steiner T, Piel J, Engel P.
Schmidt K, et al. Among authors: leopold messer s.
Elife. 2023 Apr 14;12:e76182. doi: 10.7554/eLife.76182.
Elife. 2023.
PMID: 37057993
Free PMC article.
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Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium.
Ueoka R, Sondermann P, Leopold-Messer S, Liu Y, Suo R, Bhushan A, Vadakumchery L, Greczmiel U, Yashiroda Y, Kimura H, Nishimura S, Hoshikawa Y, Yoshida M, Oxenius A, Matsunaga S, Williamson RT, Carreira EM, Piel J.
Ueoka R, et al. Among authors: leopold messer s.
Nat Chem. 2022 Oct;14(10):1193-1201. doi: 10.1038/s41557-022-01020-0. Epub 2022 Sep 5.
Nat Chem. 2022.
PMID: 36064972
Free PMC article.
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Identification of trans-AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors.
Kačar D, Cañedo LM, Rodríguez P, González EG, Galán B, Schleissner C, Leopold-Messer S, Piel J, Cuevas C, de la Calle F, García JL.
Kačar D, et al. Among authors: leopold messer s.
Environ Microbiol. 2021 May;23(5):2509-2521. doi: 10.1111/1462-2920.15470. Epub 2021 Apr 2.
Environ Microbiol. 2021.
PMID: 33734547
Free article.
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Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria.
Helfrich EJN, Ueoka R, Chevrette MG, Hemmerling F, Lu X, Leopold-Messer S, Minas HA, Burch AY, Lindow SE, Piel J, Medema MH.
Helfrich EJN, et al. Among authors: leopold messer s.
Nat Commun. 2021 Mar 3;12(1):1422. doi: 10.1038/s41467-021-21163-x.
Nat Commun. 2021.
PMID: 33658492
Free PMC article.
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A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds.
Moosmann P, Ecker F, Leopold-Messer S, Cahn JKB, Dieterich CL, Groll M, Piel J.
Moosmann P, et al. Among authors: leopold messer s.
Nat Chem. 2020 Oct;12(10):968-972. doi: 10.1038/s41557-020-0515-3. Epub 2020 Aug 10.
Nat Chem. 2020.
PMID: 32778689
Free PMC article.
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