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3'-axial CH2 OH substitution on glucopyranose does not increase glycogen phosphorylase inhibitory potency. QM/MM-PBSA calculations suggest why.
Manta S, Xipnitou A, Kiritsis C, Kantsadi AL, Hayes JM, Skamnaki VT, Lamprakis C, Kontou M, Zoumpoulakis P, Zographos SE, Leonidas DD, Komiotis D. Manta S, et al. Among authors: leonidas dd. Chem Biol Drug Des. 2012 May;79(5):663-73. doi: 10.1111/j.1747-0285.2012.01349.x. Epub 2012 Mar 7. Chem Biol Drug Des. 2012. PMID: 22296957
The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment.
Kantsadi AL, Manta S, Psarra AM, Dimopoulou A, Kiritsis C, Parmenopoulou V, Skamnaki VT, Zoumpoulakis P, Zographos SE, Leonidas DD, Komiotis D. Kantsadi AL, et al. Among authors: leonidas dd. Eur J Med Chem. 2012 Aug;54:740-9. doi: 10.1016/j.ejmech.2012.06.029. Epub 2012 Jun 22. Eur J Med Chem. 2012. PMID: 22770609
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.
Parmenopoulou V, Chatzileontiadou DS, Manta S, Bougiatioti S, Maragozidis P, Gkaragkouni DN, Kaffesaki E, Kantsadi AL, Skamnaki VT, Zographos SE, Zounpoulakis P, Balatsos NA, Komiotis D, Leonidas DD. Parmenopoulou V, et al. Among authors: leonidas dd. Bioorg Med Chem. 2012 Dec 15;20(24):7184-93. doi: 10.1016/j.bmc.2012.09.067. Epub 2012 Oct 16. Bioorg Med Chem. 2012. PMID: 23122937
112 results