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Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma.
Kent LN, Bae S, Tsai SY, Tang X, Srivastava A, Koivisto C, Martin CK, Ridolfi E, Miller GC, Zorko SM, Plevris E, Hadjiyannis Y, Perez M, Nolan E, Kladney R, Westendorp B, de Bruin A, Fernandez S, Rosol TJ, Pohar KS, Pipas JM, Leone G. Kent LN, et al. Among authors: leone g. J Clin Invest. 2017 Mar 1;127(3):830-842. doi: 10.1172/JCI87583. Epub 2017 Jan 30. J Clin Invest. 2017. PMID: 28134624 Free PMC article.
E2f8 mediates tumor suppression in postnatal liver development.
Kent LN, Rakijas JB, Pandit SK, Westendorp B, Chen HZ, Huntington JT, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G. Kent LN, et al. Among authors: leone g. J Clin Invest. 2016 Aug 1;126(8):2955-69. doi: 10.1172/JCI85506. Epub 2016 Jul 25. J Clin Invest. 2016. PMID: 27454291 Free PMC article.
Mouse development with a single E2F activator.
Tsai SY, Opavsky R, Sharma N, Wu L, Naidu S, Nolan E, Feria-Arias E, Timmers C, Opavska J, de Bruin A, Chong JL, Trikha P, Fernandez SA, Stromberg P, Rosol TJ, Leone G. Tsai SY, et al. Among authors: leone g. Nature. 2008 Aug 28;454(7208):1137-41. doi: 10.1038/nature07066. Epub 2008 Jun 25. Nature. 2008. PMID: 18594513 Free PMC article.
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
Liu H, Tang X, Srivastava A, Pécot T, Daniel P, Hemmelgarn B, Reyes S, Fackler N, Bajwa A, Kladney R, Koivisto C, Chen Z, Wang Q, Huang K, Machiraju R, Sáenz-Robles MT, Cantalupo P, Pipas JM, Leone G. Liu H, et al. Among authors: leone g. Nat Cell Biol. 2015 Aug;17(8):1036-48. doi: 10.1038/ncb3210. Epub 2015 Jul 20. Nat Cell Biol. 2015. PMID: 26192440 Free PMC article.
Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice.
Tang X, Liu H, Srivastava A, Pécot T, Chen Z, Wang Q, Huang K, Sáenz-Robles MT, Cantalupo P, Pipas J, Leone G. Tang X, et al. Among authors: leone g. Sci Data. 2016 Feb 16;3:160008. doi: 10.1038/sdata.2016.8. Sci Data. 2016. PMID: 26881867 Free PMC article.
The broken cycle: E2F dysfunction in cancer.
Kent LN, Leone G. Kent LN, et al. Among authors: leone g. Nat Rev Cancer. 2019 Jun;19(6):326-338. doi: 10.1038/s41568-019-0143-7. Nat Rev Cancer. 2019. PMID: 31053804 Review.
1,326 results