Leonard WJ - Search Results

1

An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness.

Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, Zhuang X, Mitra S, Lin JX, Gattinoni L, Powell JD, Restifo NP, Garcia KC, Leonard WJ. Mo F, et al. Among authors: leonard wj. Nature. 2021 Sep;597(7877):544-548. doi: 10.1038/s41586-021-03861-0. Epub 2021 Sep 15. Nature. 2021. PMID: 34526724 Free PMC article.

2

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.

Migone TS, Lin JX, Cereseto A, Mulloy JC, O'Shea JJ, Franchini G, Leonard WJ. Migone TS, et al. Among authors: leonard wj. Science. 1995 Jul 7;269(5220):79-81. doi: 10.1126/science.7604283. Science. 1995. PMID: 7604283

3

Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.

John S, Reeves RB, Lin JX, Child R, Leiden JM, Thompson CB, Leonard WJ. John S, et al. Among authors: leonard wj. Mol Cell Biol. 1995 Mar;15(3):1786-96. doi: 10.1128/MCB.15.3.1786. Mol Cell Biol. 1995. PMID: 7862168 Free PMC article.

4

Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling.

Nakamura Y, Russell SM, Mess SA, Friedmann M, Erdos M, Francois C, Jacques Y, Adelstein S, Leonard WJ. Nakamura Y, et al. Among authors: leonard wj. Nature. 1994 May 26;369(6478):330-3. doi: 10.1038/369330a0. Nature. 1994. PMID: 8183373

5

Characterization of the human interleukin-2 receptor beta-chain gene promoter: regulation of promoter activity by ets gene products.

Lin JX, Bhat NK, John S, Queale WS, Leonard WJ. Lin JX, et al. Among authors: leonard wj. Mol Cell Biol. 1993 Oct;13(10):6201-10. doi: 10.1128/mcb.13.10.6201-6210.1993. Mol Cell Biol. 1993. PMID: 8413220 Free PMC article.

6

Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.

Lin JX, Mietz J, Modi WS, John S, Leonard WJ. Lin JX, et al. Among authors: leonard wj. J Biol Chem. 1996 May 3;271(18):10738-44. J Biol Chem. 1996. PMID: 8631883 Free article.

7

STATs and cytokine specificity.

Leonard WJ. Leonard WJ. Nat Med. 1996 Sep;2(9):968-9. doi: 10.1038/nm0996-968. Nat Med. 1996. PMID: 8782447 No abstract available.

8

The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor beta-chain promoter through noncanonical Egr and Sp1 binding sites.

Lin JX, Leonard WJ. Lin JX, et al. Among authors: leonard wj. Mol Cell Biol. 1997 Jul;17(7):3714-22. doi: 10.1128/MCB.17.7.3714. Mol Cell Biol. 1997. PMID: 9199305 Free PMC article.

9

Signaling from the IL-2 receptor to the nucleus.

Lin JX, Leonard WJ. Lin JX, et al. Among authors: leonard wj. Cytokine Growth Factor Rev. 1997 Dec;8(4):313-32. doi: 10.1016/s1359-6101(97)00021-x. Cytokine Growth Factor Rev. 1997. PMID: 9620644 Review.

10

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency.

Puel A, Ziegler SF, Buckley RH, Leonard WJ. Puel A, et al. Among authors: leonard wj. Nat Genet. 1998 Dec;20(4):394-7. doi: 10.1038/3877. Nat Genet. 1998. PMID: 9843216

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