Leonard DA - Search Results

1

Class D β-lactamases: a reappraisal after five decades.

Leonard DA, Bonomo RA, Powers RA. Leonard DA, et al. Acc Chem Res. 2013 Nov 19;46(11):2407-15. doi: 10.1021/ar300327a. Epub 2013 Jul 31. Acc Chem Res. 2013. PMID: 23902256 Free PMC article. Review.

2

Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme.

Schneider KD, Bethel CR, Distler AM, Hujer AM, Bonomo RA, Leonard DA. Schneider KD, et al. Among authors: leonard da. Biochemistry. 2009 Jul 7;48(26):6136-45. doi: 10.1021/bi900448u. Biochemistry. 2009. PMID: 19485421 Free PMC article.

3

The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem.

Schneider KD, Karpen ME, Bonomo RA, Leonard DA, Powers RA. Schneider KD, et al. Among authors: leonard da. Biochemistry. 2009 Dec 22;48(50):11840-7. doi: 10.1021/bi901690r. Biochemistry. 2009. PMID: 19919101 Free PMC article.

4

Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem.

Schneider KD, Ortega CJ, Renck NA, Bonomo RA, Powers RA, Leonard DA. Schneider KD, et al. Among authors: leonard da. J Mol Biol. 2011 Mar 4;406(4):583-94. doi: 10.1016/j.jmb.2010.12.042. Epub 2011 Jan 6. J Mol Biol. 2011. PMID: 21215758 Free PMC article.

5

Structures of the class D Carbapenemases OXA-23 and OXA-146: mechanistic basis of activity against carbapenems, extended-spectrum cephalosporins, and aztreonam.

Kaitany KC, Klinger NV, June CM, Ramey ME, Bonomo RA, Powers RA, Leonard DA. Kaitany KC, et al. Among authors: leonard da. Antimicrob Agents Chemother. 2013 Oct;57(10):4848-55. doi: 10.1128/AAC.00762-13. Epub 2013 Jul 22. Antimicrob Agents Chemother. 2013. PMID: 23877677 Free PMC article.

6

Structural origins of oxacillinase specificity in class D β-lactamases.

June CM, Vallier BC, Bonomo RA, Leonard DA, Powers RA. June CM, et al. Among authors: leonard da. Antimicrob Agents Chemother. 2014;58(1):333-41. doi: 10.1128/AAC.01483-13. Epub 2013 Oct 28. Antimicrob Agents Chemother. 2014. PMID: 24165180 Free PMC article.

7

A fluorescent carbapenem for structure function studies of penicillin-binding proteins, β-lactamases, and β-lactam sensors.

June CM, Vaughan RM, Ulberg LS, Bonomo RA, Witucki LA, Leonard DA. June CM, et al. Among authors: leonard da. Anal Biochem. 2014 Oct 15;463:70-4. doi: 10.1016/j.ab.2014.07.012. Epub 2014 Jul 21. Anal Biochem. 2014. PMID: 25058926 Free PMC article.

8

Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.

Mitchell JM, Clasman JR, June CM, Kaitany KC, LaFleur JR, Taracila MA, Klinger NV, Bonomo RA, Wymore T, Szarecka A, Powers RA, Leonard DA. Mitchell JM, et al. Among authors: leonard da. Biochemistry. 2015 Mar 17;54(10):1976-87. doi: 10.1021/bi501547k. Epub 2015 Mar 2. Biochemistry. 2015. PMID: 25710192 Free PMC article.

9

The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity.

June CM, Muckenthaler TJ, Schroder EC, Klamer ZL, Wawrzak Z, Powers RA, Szarecka A, Leonard DA. June CM, et al. Among authors: leonard da. Protein Sci. 2016 Dec;25(12):2152-2163. doi: 10.1002/pro.3040. Epub 2016 Sep 26. Protein Sci. 2016. PMID: 27636561 Free PMC article.

10

Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239.

Harper TM, June CM, Taracila MA, Bonomo RA, Powers RA, Leonard DA. Harper TM, et al. Among authors: leonard da. Biochem J. 2018 Jan 11;475(1):273-288. doi: 10.1042/BCJ20170702. Biochem J. 2018. PMID: 29229762 Free PMC article.

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