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Profound Treg perturbations correlate with COVID-19 severity.
Galván-Peña S, Leon J, Chowdhary K, Michelson DA, Vijaykumar B, Yang L, Magnuson AM, Chen F, Manickas-Hill Z, Piechocka-Trocha A, Worrall DP, Hall KE, Ghebremichael M, Walker BD, Li JZ, Yu XG; MGH COVID-19 Collection & Processing Team; Mathis D, Benoist C. Galván-Peña S, et al. Among authors: leon j. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2111315118. doi: 10.1073/pnas.2111315118. Proc Natl Acad Sci U S A. 2021. PMID: 34433692 Free PMC article.
Profound Treg perturbations correlate with COVID-19 severity.
Galvan-Pena S, Leon J, Chowdhary K, Michelson DA, Vijaykumar B, Yang L, Magnuson A, Manickas-Hill Z, Piechocka-Trocha A, Worrall DP, Hall KE, Ghebremichael M, Walker BD, Li JZ, Yu XG, Mathis D, Benoist C. Galvan-Pena S, et al. Among authors: leon j. bioRxiv [Preprint]. 2020 Dec 15:2020.12.11.416180. doi: 10.1101/2020.12.11.416180. bioRxiv. 2020. PMID: 33330871 Free PMC article. Updated. Preprint.
A combination of cyclophosphamide and interleukin-2 allows CD4+ T cells converted to Tregs to control scurfy syndrome.
Delville M, Bellier F, Leon J, Klifa R, Lizot S, Vinçon H, Sobrino S, Thouenon R, Marchal A, Garrigue A, Olivré J, Charbonnier S, Lagresle-Peyrou C, Amendola M, Schambach A, Gross D, Lamarthée B, Benoist C, Zuber J, André I, Cavazzana M, Six E. Delville M, et al. Among authors: leon j. Blood. 2021 Apr 29;137(17):2326-2336. doi: 10.1182/blood.2020009187. Blood. 2021. PMID: 33545713 Free PMC article.
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations.
Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, Garcia-Lloret MI, Ruemmele FM, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, André I, Chatila TA, Mathis D, Benoist C. Zemmour D, et al. Among authors: leon j. Nat Immunol. 2021 May;22(5):607-619. doi: 10.1038/s41590-021-00910-8. Epub 2021 Apr 8. Nat Immunol. 2021. PMID: 33833438 Free PMC article.
Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction.
Lamarthée B, Marchal A, Charbonnier S, Blein T, Leon J, Martin E, Rabaux L, Vogt K, Titeux M, Delville M, Vinçon H, Six E, Pallet N, Michonneau D, Anglicheau D, Legendre C, Taupin JL, Nemazanyy I, Sawitzki B, Latour S, Cavazzana M, André I, Zuber J. Lamarthée B, et al. Among authors: leon j. Nat Commun. 2021 Nov 8;12(1):6446. doi: 10.1038/s41467-021-26844-1. Nat Commun. 2021. PMID: 34750385 Free PMC article.
2,154 results