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ClpC2 protects mycobacteria against a natural antibiotic targeting ClpC1-dependent protein degradation.
Commun Biol. 2023 Mar 21;6(1):301. doi: 10.1038/s42003-023-04658-9.
Commun Biol. 2023.
PMID: 36944713
Free PMC article.
The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
Leodolter J, Warweg J, Weber-Ban E.
Leodolter J, et al.
PLoS One. 2015 May 1;10(5):e0125345. doi: 10.1371/journal.pone.0125345. eCollection 2015.
PLoS One. 2015.
PMID: 25933022
Free PMC article.
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Genome-wide interaction screen for Mycobacterium tuberculosis ClpCP protease reveals toxin-antitoxin systems as a major substrate class.
Ziemski M, Leodolter J, Taylor G, Kerschenmeyer A, Weber-Ban E.
Ziemski M, et al. Among authors: leodolter j.
FEBS J. 2021 Jan;288(1):111-126. doi: 10.1111/febs.15335. Epub 2020 May 12.
FEBS J. 2021.
PMID: 32301575
Free article.
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BacPROTACs mediate targeted protein degradation in bacteria.
Morreale FE, Kleine S, Leodolter J, Junker S, Hoi DM, Ovchinnikov S, Okun A, Kley J, Kurzbauer R, Junk L, Guha S, Podlesainski D, Kazmaier U, Boehmelt G, Weinstabl H, Rumpel K, Schmiedel VM, Hartl M, Haselbach D, Meinhart A, Kaiser M, Clausen T.
Morreale FE, et al. Among authors: leodolter j.
Cell. 2022 Jun 23;185(13):2338-2353.e18. doi: 10.1016/j.cell.2022.05.009. Epub 2022 Jun 3.
Cell. 2022.
PMID: 35662409
Free PMC article.
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival.
Hoi DM, Junker S, Junk L, Schwechel K, Fischel K, Podlesainski D, Hawkins PME, van Geelen L, Kaschani F, Leodolter J, Morreale FE, Kleine S, Guha S, Rumpel K, Schmiedel VM, Weinstabl H, Meinhart A, Payne RJ, Kaiser M, Hartl M, Boehmelt G, Kazmaier U, Kalscheuer R, Clausen T.
Hoi DM, et al. Among authors: leodolter j.
Cell. 2023 May 11;186(10):2176-2192.e22. doi: 10.1016/j.cell.2023.04.009. Epub 2023 May 2.
Cell. 2023.
PMID: 37137307
Free article.
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McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation.
Hajdusits B, Suskiewicz MJ, Hundt N, Meinhart A, Kurzbauer R, Leodolter J, Kukura P, Clausen T.
Hajdusits B, et al. Among authors: leodolter j.
Elife. 2021 Jul 30;10:e63505. doi: 10.7554/eLife.63505.
Elife. 2021.
PMID: 34328418
Free PMC article.
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Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria.
Junk L, Schmiedel VM, Guha S, Fischel K, Greb P, Vill K, Krisilia V, van Geelen L, Rumpel K, Kaur P, Krishnamurthy RV, Narayanan S, Shandil RK, Singh M, Kofink C, Mantoulidis A, Biber P, Gmaschitz G, Kazmaier U, Meinhart A, Leodolter J, Hoi D, Junker S, Morreale FE, Clausen T, Kalscheuer R, Weinstabl H, Boehmelt G.
Junk L, et al. Among authors: leodolter j.
Nat Commun. 2024 Mar 5;15(1):2005. doi: 10.1038/s41467-024-46218-7.
Nat Commun. 2024.
PMID: 38443338
Free PMC article.
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