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Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine.
Xiang AX, Webber SE, Kerr BM, Rueden EJ, Lennox JR, Haley GJ, Wang T, Ng JS, Herbert MR, Clark DL, Banh VN, Li W, Fletcher SP, Steffy KR, Bartkowski DM, Kirkovsky LI, Bauman LA, Averett DR. Xiang AX, et al. Among authors: lennox jr. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40. doi: 10.1080/15257770701490472. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18066870 Clinical Trial.
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
Butera JA, Antane MM, Antane SA, Argentieri TM, Freeden C, Graceffa RF, Hirth BH, Jenkins D, Lennox JR, Matelan E, Norton NW, Quagliato D, Sheldon JH, Spinelli W, Warga D, Wojdan A, Woods M. Butera JA, et al. Among authors: lennox jr. J Med Chem. 2000 Mar 23;43(6):1187-202. doi: 10.1021/jm9905099. J Med Chem. 2000. PMID: 10737752
Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 2. Selective and potent benzylamino cyclobutenediones.
Gilbert AM, Antane MM, Argentieri TM, Butera JA, Francisco GD, Freeden C, Gundersen EG, Graceffa RF, Herbst D, Hirth BH, Lennox JR, McFarlane G, Norton NW, Quagliato D, Sheldon JH, Warga D, Wojdan A, Woods M. Gilbert AM, et al. Among authors: lennox jr. J Med Chem. 2000 Mar 23;43(6):1203-14. doi: 10.1021/jm9905108. J Med Chem. 2000. PMID: 10737753