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Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine.
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40. doi: 10.1080/15257770701490472.
Nucleosides Nucleotides Nucleic Acids. 2007.
PMID: 18066870
Clinical Trial.
Enantiospecific synthesis of annulated nicotine analogues from D-glutamic acid. 7-Azabicyclo[2.2.1]heptano[2.3-c]pyridines.
Lennox JR, Turner SC, Rapoport H.
Lennox JR, et al.
J Org Chem. 2001 Oct 19;66(21):7078-83. doi: 10.1021/jo010534y.
J Org Chem. 2001.
PMID: 11597233
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Synthetic Studies of Antitumor Macrolide Rhizoxin: Stereoselective Syntheses of the C(1)-C(9) and C(12)-C(26) Subunits.
Burke SD, Hong J, Lennox JR, Mongin AP.
Burke SD, et al. Among authors: lennox jr.
J Org Chem. 1998 Oct 2;63(20):6952-6967. doi: 10.1021/jo980754k.
J Org Chem. 1998.
PMID: 11672317
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Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 1. N-Cyanoguanidine bioisosteres possessing in vivo bladder selectivity.
Butera JA, Antane MM, Antane SA, Argentieri TM, Freeden C, Graceffa RF, Hirth BH, Jenkins D, Lennox JR, Matelan E, Norton NW, Quagliato D, Sheldon JH, Spinelli W, Warga D, Wojdan A, Woods M.
Butera JA, et al. Among authors: lennox jr.
J Med Chem. 2000 Mar 23;43(6):1187-202. doi: 10.1021/jm9905099.
J Med Chem. 2000.
PMID: 10737752
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Design and SAR of novel potassium channel openers targeted for urge urinary incontinence. 2. Selective and potent benzylamino cyclobutenediones.
Gilbert AM, Antane MM, Argentieri TM, Butera JA, Francisco GD, Freeden C, Gundersen EG, Graceffa RF, Herbst D, Hirth BH, Lennox JR, McFarlane G, Norton NW, Quagliato D, Sheldon JH, Warga D, Wojdan A, Woods M.
Gilbert AM, et al. Among authors: lennox jr.
J Med Chem. 2000 Mar 23;43(6):1203-14. doi: 10.1021/jm9905108.
J Med Chem. 2000.
PMID: 10737753
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Synthesis and potassium channel opening activity of substituted 10H-benzo[4,5]furo[3,2-b]indole-and 5,10-dihydro-indeno[1,2-b]indole-1-carboxylic acids.
Butera JA, Antane SA, Hirth B, Lennox JR, Sheldon JH, Norton NW, Warga D, Argentieri TM.
Butera JA, et al. Among authors: lennox jr.
Bioorg Med Chem Lett. 2001 Aug 20;11(16):2093-7. doi: 10.1016/s0960-894x(01)00385-7.
Bioorg Med Chem Lett. 2001.
PMID: 11514146
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Synthesis and bladder smooth muscle relaxing properties of substituted 3-amino-4-aryl-(and aralkyl-)cyclobut-3-ene-1,2-diones.
Butera JA, Jenkins DJ, Lennox JR, Sheldon JH, Norton NW, Warga D, Argentieri TM.
Butera JA, et al. Among authors: lennox jr.
Bioorg Med Chem Lett. 2005 May 16;15(10):2495-501. doi: 10.1016/j.bmcl.2005.03.073.
Bioorg Med Chem Lett. 2005.
PMID: 15863304
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