Lenhoff AM - Search Results

1

Cell therapy biomanufacturing: integrating biomaterial and flow-based membrane technologies for production of engineered T-cells.

Bomb K, LeValley PJ, Woodward I, Cassel SE, Sutherland BP, Bhattacharjee A, Yun Z, Steen J, Kurdzo E, McCoskey J, Burris D, Levine K, Carbrello C, Lenhoff AM, Fromen CA, Kloxin AM. Bomb K, et al. Among authors: lenhoff am. Adv Mater Technol. 2023 Mar 24;8(6):2201155. doi: 10.1002/admt.202201155. Epub 2023 Jan 25. Adv Mater Technol. 2023. PMID: 37600966 Free PMC article.

2

Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents.

Sripada SA, Chu W, Williams TI, Teten MA, Mosley BJ, Carbonell RG, Lenhoff AM, Cramer SM, Bill J, Yigzaw Y, Roush DJ, Menegatti S. Sripada SA, et al. Among authors: lenhoff am. Biotechnol Bioeng. 2022 Jul;119(7):1873-1889. doi: 10.1002/bit.28096. Epub 2022 Apr 22. Biotechnol Bioeng. 2022. PMID: 35377460

3

Modeling scalability of impurity precipitation in downstream biomanufacturing.

Guo J, Traylor SJ, Agoub M, Jin W, Hua H, Diemer RB, Xu X, Ghose S, Li ZJ, Lenhoff AM. Guo J, et al. Among authors: lenhoff am. Biotechnol Prog. 2024 Mar 27:e3454. doi: 10.1002/btpr.3454. Online ahead of print. Biotechnol Prog. 2024. PMID: 38539261

4

Knockout of a difficult-to-remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations.

Chiu J, Valente KN, Levy NE, Min L, Lenhoff AM, Lee KH. Chiu J, et al. Among authors: lenhoff am. Biotechnol Bioeng. 2017 May;114(5):1006-1015. doi: 10.1002/bit.26237. Epub 2016 Dec 27. Biotechnol Bioeng. 2017. PMID: 27943242 Free PMC article.

5

Applications of proteomic methods for CHO host cell protein characterization in biopharmaceutical manufacturing.

Valente KN, Levy NE, Lee KH, Lenhoff AM. Valente KN, et al. Among authors: lenhoff am. Curr Opin Biotechnol. 2018 Oct;53:144-150. doi: 10.1016/j.copbio.2018.01.004. Epub 2018 Feb 3. Curr Opin Biotechnol. 2018. PMID: 29414072 Review.

6

Characterization and implications of host-cell protein aggregates in biopharmaceutical processing.

Oh YH, Becker ML, Mendola KM, Choe LH, Min L, Lee KH, Yigzaw Y, Seay A, Bill J, Li X, Roush DJ, Cramer SM, Menegatti S, Lenhoff AM. Oh YH, et al. Among authors: lenhoff am. Biotechnol Bioeng. 2023 Apr;120(4):1068-1080. doi: 10.1002/bit.28325. Epub 2023 Jan 12. Biotechnol Bioeng. 2023. PMID: 36585356

7

Behavior of host-cell-protein-rich aggregates in antibody capture and polishing chromatography.

Herman CE, Min L, Choe LH, Maurer RW, Xu X, Ghose S, Lee KH, Lenhoff AM. Herman CE, et al. Among authors: lenhoff am. J Chromatogr A. 2023 Aug 2;1702:464081. doi: 10.1016/j.chroma.2023.464081. Epub 2023 May 18. J Chromatogr A. 2023. PMID: 37244165

8

Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing.

Oh YH, Mendola KM, Choe LH, Min L, Lavoie AR, Sripada SA, Williams TI, Lee KH, Yigzaw Y, Seay A, Bill J, Li X, Roush DJ, Cramer SM, Menegatti S, Lenhoff AM. Oh YH, et al. Among authors: lenhoff am. Biotechnol Bioeng. 2024 Jan;121(1):291-305. doi: 10.1002/bit.28568. Epub 2023 Oct 25. Biotechnol Bioeng. 2024. PMID: 37877536

9

Predictive mechanistic modeling of loading and elution in protein A chromatography.

Bhoyar S, Kumar V, Foster M, Xu X, Traylor SJ, Guo J, Lenhoff AM. Bhoyar S, et al. Among authors: lenhoff am. J Chromatogr A. 2024 Jan 4;1713:464558. doi: 10.1016/j.chroma.2023.464558. Epub 2023 Dec 4. J Chromatogr A. 2024. PMID: 38096684

10

Silica-based strong anion exchange media for protein purification.

Gu F, Chodavarapu K, McCreary D, Plitt TA, Tamoria E, Ni M, Burnham JJ, Peters M, Lenhoff AM. Gu F, et al. Among authors: lenhoff am. J Chromatogr A. 2015 Jan 9;1376:53-63. doi: 10.1016/j.chroma.2014.11.082. Epub 2014 Dec 8. J Chromatogr A. 2015. PMID: 25537176

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