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Programming inactive RNA-binding small molecules into bioactive degraders.
Nature. 2023 Jun;618(7963):169-179. doi: 10.1038/s41586-023-06091-8. Epub 2023 May 24.
Nature. 2023.
PMID: 37225982
Free PMC article.
Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor.
Benhamou RI, Choudhary S, Lekah E, Tong Y, Disney MD.
Benhamou RI, et al. Among authors: lekah e.
ACS Chem Biol. 2022 Jan 21;17(1):5-10. doi: 10.1021/acschembio.1c00395. Epub 2021 Dec 13.
ACS Chem Biol. 2022.
PMID: 34898169
Free PMC article.
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Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions.
Haniff HS, Knerr L, Liu X, Crynen G, Boström J, Abegg D, Adibekian A, Lekah E, Wang KW, Cameron MD, Yildirim I, Lemurell M, Disney MD.
Haniff HS, et al. Among authors: lekah e.
Nat Chem. 2020 Oct;12(10):952-961. doi: 10.1038/s41557-020-0514-4. Epub 2020 Aug 24.
Nat Chem. 2020.
PMID: 32839603
Free PMC article.
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Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer's Disease.
Liu X, Hebron ML, Mulki S, Wang C, Lekah E, Ferrante D, Shi W, Kurd-Misto B, Moussa C.
Liu X, et al. Among authors: lekah e.
J Alzheimers Dis. 2019;72(2):425-441. doi: 10.3233/JAD-190635.
J Alzheimers Dis. 2019.
PMID: 31594232
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