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TYK2 kinase activity is required for functional type I interferon responses in vivo.
Prchal-Murphy M, Semper C, Lassnig C, Wallner B, Gausterer C, Teppner-Klymiuk I, Kobolak J, Müller S, Kolbe T, Karaghiosoff M, Dinnyés A, Rülicke T, Leitner NR, Strobl B, Müller M. Prchal-Murphy M, et al. Among authors: leitner nr. PLoS One. 2012;7(6):e39141. doi: 10.1371/journal.pone.0039141. Epub 2012 Jun 18. PLoS One. 2012. PMID: 22723949 Free PMC article.
Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.
Vielnascher RM, Hainzl E, Leitner NR, Rammerstorfer M, Popp D, Witalisz A, Rom R, Karaghiosoff M, Kolbe T, Müller S, Rülicke T, Lassnig C, Strobl B, Müller M. Vielnascher RM, et al. Among authors: leitner nr. Transgenic Res. 2014 Jun;23(3):519-29. doi: 10.1007/s11248-014-9795-y. Epub 2014 Apr 3. Transgenic Res. 2014. PMID: 24696087
A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).
Grunert T, Leitner NR, Marchetti-Deschmann M, Miller I, Wallner B, Radwan M, Vogl C, Kolbe T, Kratky D, Gemeiner M, Allmaier G, Müller M, Strobl B. Grunert T, et al. Among authors: leitner nr. J Proteomics. 2011 Nov 18;74(12):2866-80. doi: 10.1016/j.jprot.2011.07.006. Epub 2011 Jul 23. J Proteomics. 2011. PMID: 21787891 Free PMC article.
A time- and dose-dependent STAT1 expression system.
Leitner NR, Strobl B, Bokor M, Painz R, Kolbe T, Rülicke T, Müller M, Karaghiosoff M. Leitner NR, et al. BMC Biotechnol. 2006 Dec 21;6:48. doi: 10.1186/1472-6750-6-48. BMC Biotechnol. 2006. PMID: 17184522 Free PMC article.
STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.
Semper C, Leitner NR, Lassnig C, Parrini M, Mahlakõiv T, Rammerstorfer M, Lorenz K, Rigler D, Müller S, Kolbe T, Vogl C, Rülicke T, Staeheli P, Decker T, Müller M, Strobl B. Semper C, et al. Among authors: leitner nr. Mol Cell Biol. 2014 Jun;34(12):2235-48. doi: 10.1128/MCB.00295-14. Epub 2014 Apr 7. Mol Cell Biol. 2014. PMID: 24710278 Free PMC article.
Generation of mice with a conditional Stat1 null allele.
Wallner B, Leitner NR, Vielnascher RM, Kernbauer E, Kolbe T, Karaghiosoff M, Rülicke T, Decker T, Müller M. Wallner B, et al. Among authors: leitner nr. Transgenic Res. 2012 Feb;21(1):217-24. doi: 10.1007/s11248-011-9519-5. Epub 2011 May 7. Transgenic Res. 2012. PMID: 21553074
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