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A Multitrait Locus Regulates Sarbecovirus Pathogenesis.
Schäfer A, Leist SR, Gralinski LE, Martinez DR, Winkler ES, Okuda K, Hawkins PE, Gully KL, Graham RL, Scobey DT, Bell TA, Hock P, Shaw GD, Loome JF, Madden EA, Anderson E, Baxter VK, Taft-Benz SA, Zweigart MR, May SR, Dong S, Clark M, Miller DR, Lynch RM, Heise MT, Tisch R, Boucher RC, Pardo Manuel de Villena F, Montgomery SA, Diamond MS, Ferris MT, Baric RS. Schäfer A, et al. Among authors: leist sr. mBio. 2022 Aug 30;13(4):e0145422. doi: 10.1128/mbio.01454-22. Epub 2022 Jul 12. mBio. 2022. PMID: 35862771 Free PMC article.
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.
Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Sheahan TP, et al. Among authors: leist sr. Sci Transl Med. 2017 Jun 28;9(396):eaal3653. doi: 10.1126/scitranslmed.aal3653. Sci Transl Med. 2017. PMID: 28659436 Free PMC article.
Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis.
Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, Graham RL, McAnarney ET, Stratton KG, Cockrell AS, Debbink K, Sims AC, Waters KM, Baric RS. Menachery VD, et al. Among authors: leist sr. mSphere. 2017 Nov 15;2(6):e00346-17. doi: 10.1128/mSphere.00346-17. eCollection 2017 Nov-Dec. mSphere. 2017. PMID: 29152578 Free PMC article.
Of mice and men: the host response to influenza virus infection.
Kollmus H, Pilzner C, Leist SR, Heise M, Geffers R, Schughart K. Kollmus H, et al. Among authors: leist sr. Mamm Genome. 2018 Aug;29(7-8):446-470. doi: 10.1007/s00335-018-9750-y. Epub 2018 Jun 15. Mamm Genome. 2018. PMID: 29947965 Free PMC article.
Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines.
Menachery VD, Gralinski LE, Mitchell HD, Dinnon KH 3rd, Leist SR, Yount BL Jr, McAnarney ET, Graham RL, Waters KM, Baric RS. Menachery VD, et al. Among authors: leist sr. J Virol. 2018 Aug 16;92(17):e00710-18. doi: 10.1128/JVI.00710-18. Print 2018 Sep 1. J Virol. 2018. PMID: 29976657 Free PMC article.
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV.
Sheahan TP, Sims AC, Leist SR, Schäfer A, Won J, Brown AJ, Montgomery SA, Hogg A, Babusis D, Clarke MO, Spahn JE, Bauer L, Sellers S, Porter D, Feng JY, Cihlar T, Jordan R, Denison MR, Baric RS. Sheahan TP, et al. Among authors: leist sr. Nat Commun. 2020 Jan 10;11(1):222. doi: 10.1038/s41467-019-13940-6. Nat Commun. 2020. PMID: 31924756 Free PMC article.
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