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Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity.
Fernández-Díaz CM, Merino B, López-Acosta JF, Cidad P, de la Fuente MA, Lobatón CD, Moreno A, Leissring MA, Perdomo G, Cózar-Castellano I. Fernández-Díaz CM, et al. Among authors: leissring ma. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E805-E819. doi: 10.1152/ajpendo.00040.2019. Epub 2019 Sep 3. Am J Physiol Endocrinol Metab. 2019. PMID: 31479304 Free PMC article.
Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice.
Villa-Pérez P, Merino B, Fernández-Díaz CM, Cidad P, Lobatón CD, Moreno A, Muturi HT, Ghadieh HE, Najjar SM, Leissring MA, Cózar-Castellano I, Perdomo G. Villa-Pérez P, et al. Among authors: leissring ma. Metabolism. 2018 Nov;88:1-11. doi: 10.1016/j.metabol.2018.08.001. Epub 2018 Aug 8. Metabolism. 2018. PMID: 30098324 Free PMC article.
Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme.
González-Casimiro CM, Merino B, Casanueva-Álvarez E, Postigo-Casado T, Cámara-Torres P, Fernández-Díaz CM, Leissring MA, Cózar-Castellano I, Perdomo G. González-Casimiro CM, et al. Among authors: leissring ma. Biomedicines. 2021 Jan 17;9(1):86. doi: 10.3390/biomedicines9010086. Biomedicines. 2021. PMID: 33477364 Free PMC article. Review.
Targeting Insulin-Degrading Enzyme in Insulin Clearance.
Leissring MA, González-Casimiro CM, Merino B, Suire CN, Perdomo G. Leissring MA, et al. Int J Mol Sci. 2021 Feb 24;22(5):2235. doi: 10.3390/ijms22052235. Int J Mol Sci. 2021. PMID: 33668109 Free PMC article. Review.
Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme.
Adamek RN, Suire CN, Stokes RW, Brizuela MK, Cohen SM, Leissring MA. Adamek RN, et al. Among authors: leissring ma. ChemMedChem. 2021 Jun 7;16(11):1775-1787. doi: 10.1002/cmdc.202100111. Epub 2021 Mar 31. ChemMedChem. 2021. PMID: 33686743 Free PMC article.
66 results