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SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner.
Saccon TD, Mousovich-Neto F, Ludwig RG, Carregari VC, Dos Anjos Souza AB, Dos Passos ASC, Martini MC, Barbosa PP, de Souza GF, Muraro SP, Forato J, Amorim MR, Marques RE, Veras FP, Barreto E, Gonçalves TT, Paiva IM, Fazolini NPB, Onodera CMK, Martins Junior RB, de Araújo PHC, Batah SS, Viana RMM, de Melo DM, Fabro AT, Arruda E, Queiroz Cunha F, Cunha TM, Pretti MAM, Smith BJ, Marques-Souza H, Knittel TL, Ruiz GP, Profeta GS, Fontes-Cal TCM, Boroni M, Vinolo MAR, Farias AS, Moraes-Vieira PMM, Bizzacchi JMA, Teesalu T, Chaim FDM, Cazzo E, Chaim EA, Proença-Módena JL, Martins-de-Souza D, Osako MK, Leiria LO, Mori MA. Saccon TD, et al. Among authors: leiria lo. Nat Commun. 2022 Sep 29;13(1):5722. doi: 10.1038/s41467-022-33218-8. Nat Commun. 2022. PMID: 36175400 Free PMC article.
SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology.
Veras FP, Pontelli MC, Silva CM, Toller-Kawahisa JE, de Lima M, Nascimento DC, Schneider AH, Caetité D, Tavares LA, Paiva IM, Rosales R, Colón D, Martins R, Castro IA, Almeida GM, Lopes MIF, Benatti MN, Bonjorno LP, Giannini MC, Luppino-Assad R, Almeida SL, Vilar F, Santana R, Bollela VR, Auxiliadora-Martins M, Borges M, Miranda CH, Pazin-Filho A, da Silva LLP, Cunha LD, Zamboni DS, Dal-Pizzol F, Leiria LO, Siyuan L, Batah S, Fabro A, Mauad T, Dolhnikoff M, Duarte-Neto A, Saldiva P, Cunha TM, Alves-Filho JC, Arruda E, Louzada-Junior P, Oliveira RD, Cunha FQ. Veras FP, et al. Among authors: leiria lo. J Exp Med. 2020 Dec 7;217(12):e20201129. doi: 10.1084/jem.20201129. J Exp Med. 2020. PMID: 32926098 Free PMC article.
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation.
Sugimoto S, Mena HA, Sansbury BE, Kobayashi S, Tsuji T, Wang CH, Yin X, Huang TL, Kusuyama J, Kodani SD, Darcy J, Profeta G, Pereira N, Tanzi RE, Zhang C, Serwold T, Kokkotou E, Goodyear LJ, Cypess AM, Leiria LO, Spite M, Tseng YH. Sugimoto S, et al. Among authors: leiria lo. Nat Metab. 2022 Jun;4(6):775-790. doi: 10.1038/s42255-022-00590-0. Epub 2022 Jun 27. Nat Metab. 2022. PMID: 35760872 Free PMC article.
Impact of Microbiota Depletion by Antibiotics on SARS-CoV-2 Infection of K18-hACE2 Mice.
Rodrigues PB, Gomes GF, Angelim MKSC, Souza GF, Muraro SP, Toledo-Teixeira DA, Rattis BAC, Passos AS, Pral LP, de Rezende Rodovalho V, Dos Santos P Gomes AB, Matheus VA, Antunes ASLM, Crunfli F, Antunes KH, de Souza APD, Consonni SR, Leiria LO, Alves-Filho JC, Cunha TM, Moraes-Vieira PMM, Proença-Módena JL, R Vinolo MA. Rodrigues PB, et al. Among authors: leiria lo. Cells. 2022 Aug 18;11(16):2572. doi: 10.3390/cells11162572. Cells. 2022. PMID: 36010648 Free PMC article.
COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis.
Barreto EA, Cruz AS, Veras FP, Martins R, Bernardelli RS, Paiva IM, Lima TM, Singh Y, Guimarães RC, Damasceno S, Pereira N, Alves JM, Gonçalves TT, Forato J, Muraro SP, Souza GF, Batah SS, Proenca-Modena JL, Mori MA, Cunha FQ, Louzada-Junior P, Cunha TM, Nakaya HI, Fabro A, de Oliveira RDR, Arruda E, Réa R, Réa Neto Á, Fernandes da Silva MM, Leiria LO. Barreto EA, et al. Among authors: leiria lo. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2217119120. doi: 10.1073/pnas.2217119120. Epub 2023 May 15. Proc Natl Acad Sci U S A. 2023. PMID: 37186819 Free PMC article.
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.
Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO, Lynes MD, Kempf E, Wang CH, Sugimoto S, Nigro P, Landgraf K, Schulz T, Li Y, Emanuelli B, Kothakota S, Williams LT, Jessen N, Pedersen SB, Böttcher Y, Blüher M, Körner A, Goodyear LJ, Mohammadi M, Kahn CR, Tseng YH. Shamsi F, et al. Among authors: leiria lo. Nat Commun. 2020 Mar 17;11(1):1421. doi: 10.1038/s41467-020-15055-9. Nat Commun. 2020. PMID: 32184391 Free PMC article.
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Bartelt A, et al. Among authors: leiria lo. Nat Med. 2018 Mar;24(3):292-303. doi: 10.1038/nm.4481. Epub 2018 Feb 5. Nat Med. 2018. PMID: 29400713 Free PMC article.
39 results