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HSC Aging and Senescent Immune Remodeling.
Trends Immunol. 2015 Dec;36(12):815-824. doi: 10.1016/j.it.2015.10.008. Epub 2015 Nov 21.
Trends Immunol. 2015.
PMID: 26611154
Free PMC article.
Review.
Aged murine hematopoietic stem cells drive aging-associated immune remodeling.
Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R.
Leins H, et al.
Blood. 2018 Aug 9;132(6):565-576. doi: 10.1182/blood-2018-02-831065. Epub 2018 Jun 11.
Blood. 2018.
PMID: 29891535
Free PMC article.
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Impaired immune surveillance accelerates accumulation of senescent cells and aging.
Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V.
Ovadya Y, et al. Among authors: leins h.
Nat Commun. 2018 Dec 21;9(1):5435. doi: 10.1038/s41467-018-07825-3.
Nat Commun. 2018.
PMID: 30575733
Free PMC article.
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KDM6A, a histone demethylase, regulates stress hematopoiesis and early B-cell differentiation.
Huppertz S, Senger K, Brown A, Leins H, Eiwen K, Mulaw MA, Geiger H, Becker M.
Huppertz S, et al. Among authors: leins h.
Exp Hematol. 2021 Jul;99:32-43.e13. doi: 10.1016/j.exphem.2021.06.001. Epub 2021 Jun 12.
Exp Hematol. 2021.
PMID: 34126175
Free article.
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Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice.
Florian MC, Leins H, Gobs M, Han Y, Marka G, Soller K, Vollmer A, Sakk V, Nattamai KJ, Rayes A, Zhao X, Setchell K, Mulaw M, Wagner W, Zheng Y, Geiger H.
Florian MC, et al. Among authors: leins h.
Aging Cell. 2020 Sep;19(9):e13208. doi: 10.1111/acel.13208. Epub 2020 Aug 4.
Aging Cell. 2020.
PMID: 32755011
Free PMC article.
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