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Asymmetry in catalysis by Thermotoga maritima membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor.
Vidilaseris K, Kiriazis A, Turku A, Khattab A, Johansson NG, Leino TO, Kiuru PS, Boije Af Gennäs G, Meri S, Yli-Kauhaluoma J, Xhaard H, Goldman A. Vidilaseris K, et al. Among authors: leino to. Sci Adv. 2019 May 22;5(5):eaav7574. doi: 10.1126/sciadv.aav7574. eCollection 2019 May. Sci Adv. 2019. PMID: 31131322 Free PMC article.
A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.
Keurulainen L, Vahermo M, Puente-Felipe M, Sandoval-Izquierdo E, Crespo-Fernández B, Guijarro-López L, Huertas-Valentín L, de las Heras-Dueña L, Leino TO, Siiskonen A, Ballell-Pages L, Sanz LM, Castañeda-Casado P, Jiménez-Díaz MB, Martínez-Martínez MS, Viera S, Kiuru P, Calderón F, Yli-Kauhaluoma J. Keurulainen L, et al. Among authors: leino to. J Med Chem. 2015 Jun 11;58(11):4573-80. doi: 10.1021/acs.jmedchem.5b00114. Epub 2015 May 19. J Med Chem. 2015. PMID: 25906200
Synthesis of 1,3,6-Trisubstituted Azulenes.
Leino TO, Baumann M, Yli-Kauhaluoma J, Baxendale IR, Wallén EA. Leino TO, et al. J Org Chem. 2015 Nov 20;80(22):11513-20. doi: 10.1021/acs.joc.5b02271. Epub 2015 Nov 11. J Org Chem. 2015. PMID: 26528547
Stapled truncated orexin peptides as orexin receptor agonists.
Karhu L, Weisell J, Turunen PM, Leino TO, Pätsi H, Xhaard H, Kukkonen JP, Wallén EAA. Karhu L, et al. Among authors: leino to. Peptides. 2018 Apr;102:54-60. doi: 10.1016/j.peptides.2018.02.004. Epub 2018 Feb 21. Peptides. 2018. PMID: 29475074 Free article.
Azulene-based compounds for targeting orexin receptors.
Leino TO, Turku A, Yli-Kauhaluoma J, Kukkonen JP, Xhaard H, Wallén EAA. Leino TO, et al. Eur J Med Chem. 2018 Sep 5;157:88-100. doi: 10.1016/j.ejmech.2018.07.040. Epub 2018 Jul 20. Eur J Med Chem. 2018. PMID: 30077889
13 results