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Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.
Wijeyewickrema LC, Lameignere E, Hor L, Duncan RC, Shiba T, Travers RJ, Kapopara PR, Lei V, Smith SA, Kim H, Morrissey JH, Pike RN, Conway EM. Wijeyewickrema LC, et al. Among authors: lei v. Blood. 2016 Sep 29;128(13):1766-76. doi: 10.1182/blood-2016-02-699561. Epub 2016 Jun 23. Blood. 2016. PMID: 27338096 Free PMC article.
Polyphosphate suppresses complement via the terminal pathway.
Wat JM, Foley JH, Krisinger MJ, Ocariza LM, Lei V, Wasney GA, Lameignere E, Strynadka NC, Smith SA, Morrissey JH, Conway EM. Wat JM, et al. Among authors: lei v. Blood. 2014 Jan 30;123(5):768-76. doi: 10.1182/blood-2013-07-515726. Epub 2013 Dec 13. Blood. 2014. PMID: 24335501 Free PMC article.
Persistently elevated complement alternative pathway biomarkers in COVID-19 correlate with hypoxemia and predict in-hospital mortality.
Leatherdale A, Stukas S, Lei V, West HE, Campbell CJ, Hoiland RL, Cooper J, Wellington CL, Sekhon MS, Pryzdial ELG, Conway EM. Leatherdale A, et al. Among authors: lei v. Med Microbiol Immunol. 2022 Feb;211(1):37-48. doi: 10.1007/s00430-021-00725-2. Epub 2022 Jan 16. Med Microbiol Immunol. 2022. PMID: 35034207 Free PMC article.
Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.
Petrus P, Fernandez TL, Kwon MM, Huang JL, Lei V, Safikhan NS, Karunakaran S, O'Shannessy DJ, Zheng X, Catrina SB, Albone E, Laine J, Virtanen K, Clee SM, Kieffer TJ, Noll C, Carpentier AC, Johnson JD, Rydén M, Conway EM. Petrus P, et al. Among authors: lei v. EBioMedicine. 2019 Jun;44:489-501. doi: 10.1016/j.ebiom.2019.05.057. Epub 2019 Jun 17. EBioMedicine. 2019. PMID: 31221584 Free PMC article.
51 results