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Page 1
Effect of Ibuprofen on Skeletal Muscle of Dysferlin-Null Mice.
Collier AF, Gumerson J, Lehtimäki K, Puoliväli J, Jones JW, Kane MA, Manne S, O'Neill A, Windish HP, Ahtoniemi T, Williams BA, Albrecht DE, Bloch RJ. Collier AF, et al. Among authors: lehtimaki k. J Pharmacol Exp Ther. 2018 Mar;364(3):409-419. doi: 10.1124/jpet.117.244244. Epub 2017 Dec 28. J Pharmacol Exp Ther. 2018. PMID: 29284661 Free PMC article.
Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.
Heikkinen T, Lehtimäki K, Vartiainen N, Puoliväli J, Hendricks SJ, Glaser JR, Bradaia A, Wadel K, Touller C, Kontkanen O, Yrjänheikki JM, Buisson B, Howland D, Beaumont V, Munoz-Sanjuan I, Park LC. Heikkinen T, et al. Among authors: lehtimaki k. PLoS One. 2012;7(12):e50717. doi: 10.1371/journal.pone.0050717. Epub 2012 Dec 20. PLoS One. 2012. PMID: 23284644 Free PMC article.
mNos2 deletion and human NOS2 replacement in Alzheimer disease models.
Colton CA, Wilson JG, Everhart A, Wilcock DM, Puoliväli J, Heikkinen T, Oksman J, Jääskeläinen O, Lehtimäki K, Laitinen T, Vartiainen N, Vitek MP. Colton CA, et al. Among authors: lehtimaki k. J Neuropathol Exp Neurol. 2014 Aug;73(8):752-69. doi: 10.1097/NEN.0000000000000094. J Neuropathol Exp Neurol. 2014. PMID: 25003233 Free PMC article.
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease.
Beaumont V, Mrzljak L, Dijkman U, Freije R, Heins M, Rassoulpour A, Tombaugh G, Gelman S, Bradaia A, Steidl E, Gleyzes M, Heikkinen T, Lehtimäki K, Puoliväli J, Kontkanen O, Javier RM, Neagoe I, Deisemann H, Winkler D, Ebneth A, Khetarpal V, Toledo-Sherman L, Dominguez C, Park LC, Munoz-Sanjuan I. Beaumont V, et al. Among authors: lehtimaki k. Exp Neurol. 2016 Aug;282:99-118. doi: 10.1016/j.expneurol.2016.05.005. Epub 2016 May 6. Exp Neurol. 2016. PMID: 27163548
Systemic Delivery of Dysferlin Overlap Vectors Provides Long-Term Gene Expression and Functional Improvement for Dysferlinopathy.
Potter RA, Griffin DA, Sondergaard PC, Johnson RW, Pozsgai ER, Heller KN, Peterson EL, Lehtimäki KK, Windish HP, Mittal PJ, Albrecht DE, Mendell JR, Rodino-Klapac LR. Potter RA, et al. Among authors: lehtimaki kk. Hum Gene Ther. 2018 Jul;29(7):749-762. doi: 10.1089/hum.2017.062. Epub 2017 Jul 13. Hum Gene Ther. 2018. PMID: 28707952 Free PMC article.
Using a State-of-the-Art Toolbox to Evaluate Molecular and Functional Readouts of Antisense Oligonucleotide-Induced Exon Skipping in mdx Mice.
Datson NA, Bijl S, Janson A, Testerink J, van den Eijnde R, Weij R, Puoliväli J, Lehtimäki K, Bragge T, Ahtoniemi T, van Deutekom JC. Datson NA, et al. Among authors: lehtimaki k. Nucleic Acid Ther. 2020 Feb;30(1):50-65. doi: 10.1089/nat.2019.0824. Epub 2019 Dec 10. Nucleic Acid Ther. 2020. PMID: 31821107 Free PMC article.
A multimodal approach to identify clinically relevant biomarkers to comprehensively monitor disease progression in a mouse model of pediatric neurodegenerative disease.
Johnson TB, Brudvig JJ, Lehtimäki KK, Cain JT, White KA, Bragge T, Rytkönen J, Huhtala T, Timm D, Vihma M, Puoliväli JT, Poutiainen P, Nurmi A, Weimer JM. Johnson TB, et al. Among authors: lehtimaki kk. Prog Neurobiol. 2020 Jun;189:101789. doi: 10.1016/j.pneurobio.2020.101789. Epub 2020 Mar 18. Prog Neurobiol. 2020. PMID: 32198061
Vertigoheel promotes rodent cognitive performance in multiple memory tests.
Ott K, Heikkinen T, Lehtimäki KK, Paldanius K, Puoliväli J, Pussinen R, Andriambeloson E, Huyard B, Wagner S, Schnack C, Wahler A, von Einem B, von Arnim CAF, Burmeister Y, Weyer K, Seilheimer B. Ott K, et al. Among authors: lehtimaki kk. Front Neurosci. 2023 May 31;17:1183023. doi: 10.3389/fnins.2023.1183023. eCollection 2023. Front Neurosci. 2023. PMID: 37325043 Free PMC article.
The radical scavenger IAC (bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl) decantionate) decreases mortality, enhances cognitive functions in water maze and reduces amyloid plaque burden in hAβPP transgenic mice.
Puoliväli J, Nurmi A, Miettinen TK, Soleti A, Riccardino F, Kalesnykas G, Heikkinen T, Vartiainen N, Pussinen R, Tähtivaara L, Lehtimäki K, Yrjänheikki J, Canistro D, Sapone A, Spisni E, Paolini M. Puoliväli J, et al. Among authors: lehtimaki k. J Alzheimers Dis. 2011;27(3):499-510. doi: 10.3233/JAD-2011-110881. J Alzheimers Dis. 2011. PMID: 21821875
96 results