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Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses.
Tampere M, Pettke A, Salata C, Wallner O, Koolmeister T, Cazares-Körner A, Visnes T, Hesselman MC, Kunold E, Wiita E, Kalderén C, Lightowler M, Jemth AS, Lehtiö J, Rosenquist Å, Warpman-Berglund U, Helleday T, Mirazimi A, Jafari R, Puumalainen MR. Tampere M, et al. Among authors: lehtio j. Viruses. 2020 Dec 10;12(12):1423. doi: 10.3390/v12121423. Viruses. 2020. PMID: 33322045 Free PMC article.
Validation and development of MTH1 inhibitors for treatment of cancer.
Warpman Berglund U, Sanjiv K, Gad H, Kalderén C, Koolmeister T, Pham T, Gokturk C, Jafari R, Maddalo G, Seashore-Ludlow B, Chernobrovkin A, Manoilov A, Pateras IS, Rasti A, Jemth AS, Almlöf I, Loseva O, Visnes T, Einarsdottir BO, Gaugaz FZ, Saleh A, Platzack B, Wallner OA, Vallin KS, Henriksson M, Wakchaure P, Borhade S, Herr P, Kallberg Y, Baranczewski P, Homan EJ, Wiita E, Nagpal V, Meijer T, Schipper N, Rudd SG, Bräutigam L, Lindqvist A, Filppula A, Lee TC, Artursson P, Nilsson JA, Gorgoulis VG, Lehtiö J, Zubarev RA, Scobie M, Helleday T. Warpman Berglund U, et al. Among authors: lehtio j. Ann Oncol. 2016 Dec;27(12):2275-2283. doi: 10.1093/annonc/mdw429. Epub 2016 Nov 8. Ann Oncol. 2016. PMID: 27827301 Free article.
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
Rudd SG, Tsesmetzis N, Sanjiv K, Paulin CB, Sandhow L, Kutzner J, Hed Myrberg I, Bunten SS, Axelsson H, Zhang SM, Rasti A, Mäkelä P, Coggins SA, Tao S, Suman S, Branca RM, Mermelekas G, Wiita E, Lee S, Walfridsson J, Schinazi RF, Kim B, Lehtiö J, Rassidakis GZ, Pokrovskaja Tamm K, Warpman-Berglund U, Heyman M, Grandér D, Lehmann S, Lundbäck T, Qian H, Henter JI, Schaller T, Helleday T, Herold N. Rudd SG, et al. Among authors: lehtio j. EMBO Mol Med. 2020 Mar 6;12(3):e10419. doi: 10.15252/emmm.201910419. Epub 2020 Jan 17. EMBO Mol Med. 2020. PMID: 31950591 Free PMC article.
The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia.
Mou T, Pawitan Y, Stahl M, Vesterlund M, Deng W, Jafari R, Bohlin A, Österroos A, Siavelis L, Bäckvall H, Erkers T, Kiviluoto S, Seashore-Ludlow B, Östling P, Orre LM, Kallioniemi O, Lehmann S, Lehtiö J, Vu TN. Mou T, et al. Among authors: lehtio j. Am J Hematol. 2021 May 1;96(5):580-588. doi: 10.1002/ajh.26141. Epub 2021 Mar 10. Am J Hematol. 2021. PMID: 33625756 Free article.
Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.
Leo IR, Aswad L, Stahl M, Kunold E, Post F, Erkers T, Struyf N, Mermelekas G, Joshi RN, Gracia-Villacampa E, Östling P, Kallioniemi OP, Tamm KP, Siavelis I, Lehtiö J, Vesterlund M, Jafari R. Leo IR, et al. Among authors: lehtio j. Nat Commun. 2022 Mar 30;13(1):1691. doi: 10.1038/s41467-022-29224-5. Nat Commun. 2022. PMID: 35354797 Free PMC article.
Delineating functional and molecular impact of ex vivo sample handling in precision medicine.
Struyf N, Österroos A, Vesterlund M, Arnroth C, James T, Sunandar S, Mermelekas G, Bohlin A, Hamberg Levedahl K, Bengtzén S, Jafari R, Orre LM, Lehtiö J, Lehmann S, Östling P, Kallioniemi O, Seashore-Ludlow B, Erkers T. Struyf N, et al. Among authors: lehtio j. NPJ Precis Oncol. 2024 Feb 19;8(1):38. doi: 10.1038/s41698-024-00528-7. NPJ Precis Oncol. 2024. PMID: 38374206 Free PMC article.
Prediction model for drug response of acute myeloid leukemia patients.
Trac QT, Pawitan Y, Mou T, Erkers T, Östling P, Bohlin A, Österroos A, Vesterlund M, Jafari R, Siavelis I, Bäckvall H, Kiviluoto S, Orre LM, Rantalainen M, Lehtiö J, Lehmann S, Kallioniemi O, Vu TN. Trac QT, et al. Among authors: lehtio j. NPJ Precis Oncol. 2023 Mar 24;7(1):32. doi: 10.1038/s41698-023-00374-z. NPJ Precis Oncol. 2023. PMID: 36964195 Free PMC article.
181 results