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Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice.
van der Vorst EPC, Maas SL, Theodorou K, Peters LJF, Jin H, Rademakers T, Gijbels MJ, Rousch M, Jansen Y, Weber C, Lehrke M, Lebherz C, Yildiz D, Ludwig A, Bentzon JF, Biessen EAL, Donners MMPC. van der Vorst EPC, et al. Among authors: lehrke m. Front Cardiovasc Med. 2023 Jan 27;10:974918. doi: 10.3389/fcvm.2023.974918. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 36776254 Free PMC article.
Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease.
Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah AT, Nagai J, Li Z, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, Kim H, van Roeyen CRC, Lehrke M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders MEJ, Baan C, Gribnau J, Hoorn EJ, Steffens J, Huber TB, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS, Kramann R. Xu Y, et al. Among authors: lehrke m. Nat Genet. 2022 Nov;54(11):1690-1701. doi: 10.1038/s41588-022-01202-z. Epub 2022 Oct 27. Nat Genet. 2022. PMID: 36303074 Free PMC article.
Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health.
Harlacher E, Schulte C, Vondenhoff S, Schmitt-Kopplin P, Diederich P, Hemmers C, Moellmann J, Wollenhaupt J, Veltrop R, Biessen E, Lehrke M, Peters B, Schlieper G, Kuppe C, Floege J, Jankowski V, Marx N, Jankowski J, Noels H. Harlacher E, et al. Among authors: lehrke m. Front Cardiovasc Med. 2024 Mar 6;11:1346475. doi: 10.3389/fcvm.2024.1346475. eCollection 2024. Front Cardiovasc Med. 2024. PMID: 38510194 Free PMC article.
Position Paper on Lipid Therapy in Patients with Diabetes Mellitus.
Parhofer KG, Birkenfeld AL, Krone W, Lehrke M, Marx N, Merkel M, Schütt KS, Zirlik A, Müller-Wieland D. Parhofer KG, et al. Among authors: lehrke m. Exp Clin Endocrinol Diabetes. 2024 Feb;132(2):57-62. doi: 10.1055/a-2166-6859. Epub 2024 Jan 15. Exp Clin Endocrinol Diabetes. 2024. PMID: 38224696 No abstract available.
Mapping cardiac remodeling in chronic kidney disease.
Kaesler N, Cheng M, Nagai J, O'Sullivan J, Peisker F, Bindels EMJ, Babler A, Moellmann J, Droste P, Franciosa G, Dugourd A, Saez-Rodriguez J, Neuss S, Lehrke M, Boor P, Goettsch C, Olsen JV, Speer T, Lu TS, Lim K, Floege J, Denby L, Costa I, Kramann R. Kaesler N, et al. Among authors: lehrke m. Sci Adv. 2023 Nov 24;9(47):eadj4846. doi: 10.1126/sciadv.adj4846. Epub 2023 Nov 24. Sci Adv. 2023. PMID: 38000021 Free PMC article.
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.
Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Tornøe CW, Ryan DH; SELECT Trial Investigators. Lincoff AM, et al. N Engl J Med. 2023 Dec 14;389(24):2221-2232. doi: 10.1056/NEJMoa2307563. Epub 2023 Nov 11. N Engl J Med. 2023. PMID: 37952131 Clinical Trial.
138 results