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Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells.
Thelen M, Keller D, Lehmann J, Wennhold K, Weitz H, Bauer E, Gathof B, Brüggemann M, Kotrova M, Quaas A, Mallmann C, Chon SH, Hillmer AM, Bruns C, von Bergwelt-Baildon M, Garcia-Marquez MA, Schlößer HA. Thelen M, et al. Among authors: lehmann j. J Immunother Cancer. 2022 Dec;10(12):e005200. doi: 10.1136/jitc-2022-005200. J Immunother Cancer. 2022. PMID: 36600602 Free PMC article.
Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy.
Thelen M, Wennhold K, Lehmann J, Garcia-Marquez M, Klein S, Kochen E, Lohneis P, Lechner A, Wagener-Ryczek S, Plum PS, Velazquez Camacho O, Pfister D, Dörr F, Heldwein M, Hekmat K, Beutner D, Klussmann JP, Thangarajah F, Ratiu D, Malter W, Merkelbach-Bruse S, Bruns CJ, Quaas A, von Bergwelt-Baildon M, Schlößer HA. Thelen M, et al. Among authors: lehmann j. NPJ Precis Oncol. 2021 Jun 16;5(1):52. doi: 10.1038/s41698-021-00196-x. NPJ Precis Oncol. 2021. PMID: 34135436 Free PMC article.
CD86+ Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses.
Wennhold K, Thelen M, Lehmann J, Schran S, Preugszat E, Garcia-Marquez M, Lechner A, Shimabukuro-Vornhagen A, Ercanoglu MS, Klein F, Thangarajah F, Eidt S, Löser H, Bruns C, Quaas A, von Bergwelt-Baildon M, Schlößer HA. Wennhold K, et al. Among authors: lehmann j. Cancer Immunol Res. 2021 Sep;9(9):1098-1108. doi: 10.1158/2326-6066.CIR-20-0949. Epub 2021 Jun 21. Cancer Immunol Res. 2021. PMID: 34155067
Reverted exhaustion phenotype of circulating lymphocytes as immune correlate of anti-PD1 first-line treatment in Hodgkin lymphoma.
Garcia-Marquez MA, Thelen M, Reinke S, Keller D, Wennhold K, Lehmann J, Veldman J, Borchmann S, Rosenwald A, Sasse S, Diepstra A, Borchmann P, Engert A, Klapper W, von Bergwelt-Baildon M, Bröckelmann PJ, Schlößer HA. Garcia-Marquez MA, et al. Among authors: lehmann j. Leukemia. 2022 Mar;36(3):760-771. doi: 10.1038/s41375-021-01421-z. Epub 2021 Sep 28. Leukemia. 2022. PMID: 34584203 Free PMC article. Clinical Trial.
T-cells of invasive candidiasis patients show patterns of T-cell-exhaustion suggesting checkpoint blockade as treatment option.
Mellinghoff SC, Thelen M, Bruns C, Garcia-Marquez M, Hartmann P, Lammertz T, Lehmann J, Nowag A, Stemler J, Wennhold K, Cornely OA, von Bergwelt-Baildon MS, Schlößer HA. Mellinghoff SC, et al. Among authors: lehmann j. J Infect. 2022 Feb;84(2):237-247. doi: 10.1016/j.jinf.2021.12.009. Epub 2021 Dec 15. J Infect. 2022. PMID: 34921845 Clinical Trial.
Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance.
Datta RR, Schran S, Persa OD, Aguilar C, Thelen M, Lehmann J, Garcia-Marquez MA, Wennhold K, Preugszat E, Zentis P, von Bergwelt-Baildon MS, Quaas A, Bruns CJ, Kurschat C, Mauch C, Löser H, Stippel DL, Schlößer HA. Datta RR, et al. Among authors: lehmann j. Clin Cancer Res. 2022 Apr 14;28(8):1712-1723. doi: 10.1158/1078-0432.CCR-21-3746. Clin Cancer Res. 2022. PMID: 35191474
TIGIT+ NK cells in combination with specific gut microbiota features predict response to checkpoint inhibitor therapy in melanoma patients.
Tsakmaklis A, Farowski F, Zenner R, Lesker TR, Strowig T, Schlößer H, Lehmann J, von Bergwelt-Baildon M, Mauch C, Schlaak M, Knuever J, Schweinsberg V, Heinzerling LM, Vehreschild MJGT. Tsakmaklis A, et al. Among authors: lehmann j. BMC Cancer. 2023 Nov 28;23(1):1160. doi: 10.1186/s12885-023-11551-5. BMC Cancer. 2023. PMID: 38017389 Free PMC article.
Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides.
Garcia-Marquez MA, Thelen M, Bauer E, Maas L, Wennhold K, Lehmann J, Keller D, Nikolić M, George J, Zander T, Schröder W, Müller P, Yazbeck AM, Bruns C, Thomas R, Gathof B, Quaas A, Peifer M, Hillmer AM, von Bergwelt-Baildon M, Schlößer HA. Garcia-Marquez MA, et al. Among authors: lehmann j. J Immunother Cancer. 2024 Apr 17;12(4):e007268. doi: 10.1136/jitc-2023-007268. J Immunother Cancer. 2024. PMID: 38631707 Free PMC article.
1,474 results